Atopic dermatitis: modern possibilities of prevention
A.V. Kolerova¹, Yu.M. Krinicina<sup>1,2

1</sup> Novosibirsk State University
² Institute of Molecular Pathology and Pathomorphology, Novosibirsk

Defects of the epidermis are the entrance gate for potential allergens of the external environment, which can lead to the development of a type I hypersensitivity reaction, which underlies atopic dermatitis, asthma, allergic rhinitis, etc. Therefore, the basic method for the prevention and treatment of exacerbations of the disease and an increase in the duration of the remission period is the regular use of emollients, daily application of which to the skin of newborns reliably reduces the risk of atopic dermatitis in the future twice.
The active ingredient of the drug D-Panthenol (EGIS Pharmaceuticals PLC) — dexpanthenol, helps to compensate for the subclinical dysfunction of the skin barrier, and also prevents the development of an inflammatory reaction by replenishing skin hydration and reducing skin permeability to allergens. Lanolin and white beeswax, which are part of the drug, contribute to the restoration of the lipid composition of the skin, thereby enhancing the action of the main substance. The drug is available in two dosage forms: cream and ointment. D-Panthenol is the basic step in the treatment of atopic dermatitis according to the Federal Clinical Guidelines for the treatment of this disease, which indicates that the drug is used for any degree of severity of the pathology.

Key words: prevention of atopic dermatitis, epidermis defects, skin barrier, emollients, dexpanthenol, D-Panthenol.
For citation: Kolerova A.V., Krinicina Yu.M. Atopic dermatitis: modern possibilities of prevention // RMJ. 2018. № 8(II). P.97 –101.