Do we consider all COPD risk factors?
Baranova I.I., Leshchenko I.V.

Ural State Medical University, Yekaterinburg

Proved risk factor of the development of COPD is exposure of smoke and occupational exposures. Toxic effects of air pollutions on the human body are characterized by the development of oxidative stress, with the main source of antioxidants are foods. In 2015, Chinese researchers conducted a meta-analysis of epidemiological studies devoted to the prevalence of COPD. They determined interrelation between dietary characteristics and the risk of developing COPD. In 2012, results of metabolome assessment in COPD patients in ECLIPSE study (The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points) were published. The metabolites, which have a strong correlation with markers of cachexia, also correlated with markers of systemic inflammation. The studies have shown that when there is insufficient use of food, fasting the catabolism of proteins increases with a short-term increase in branched- chain amino acids (BCAA) in serum. The most significant for all patients with COPD is protein active utilization in metabolic processes, while in patients with emphysema and cachexia degradation  of muscle protein structures increased. Patients with emphysema detected violations creatinine synthesis and degradation of glycine. Patients with high levels of C-reactive protein, i.e. systemic inflammation phenomena has also been increased muscle protein degradation (3 methylhistidine) and utilization of BCAA.

Key words: COPD, risk factors metabolome, antioxidants, nutritional status.
For citation: Baranova I.I., Leshchenko I.V. Do we consider all COPD risk factors? // RMJ. 2017. № 3. P. 200–205.