Macrolides: efficiency and security for the treatment of pneumonia

Leshchenko I.V.

Ural State Medical University, Yekaterinburg

Early diagnosis of community-acquired pneumonia (CAP) and timely treatment largely determine the course and prognosis of the disease. The severity of the CAP is determined by the scale of Confusion-Respiratory rate-Blood pressure-65 (CRB-65) and / or systemic inflammatory response syndrome (SIRS). Macrolide antibiotics occupy a leading position in the antibacterial therapy CAP of various etiologies. A feature of azithromycin are bacteriostatic, bactericidal and immunomodulation properties and its safety. There are differences in the max-imum concentration and the duration of the original as compared with azithromycin generic drug in lung tissue. The most frequent combination antibiotic therapy is the combination of severe CAP III generation cephalosporin’s and macrolides, which reduces the risk of death by 18% in comparison with other modes of antimicrobial therapy.

Key words: community-acquired pneumonia, diagnosis, macrolides, efficiency, security.
For citation: Leshchenko I.V. Macrolides: efficiency and security for the treatment of pneumonia // RMJ. 2017. № 3. P. 232–237.