Analgesic and anti-inflammatory effects of lornoxicam: efficacy and safety
Klimova O.Yu., Berdnikova N.G., Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University

NSAIDs are amongst the most popular medical agents with broad spectrum of indications for use. They acts via inhibiting the synthesis of prostaglandins which play the key pathogenic role in inflammation, pain, and fever. Cyclooxygenase (COG) is the major molecular target for NSAIDs. Lornoxicam inhibits both COG isoenzymes, i.e., COG-1 and COG-2, and is therefore nonselective NSAID. Pharmacokinetics and pharmacodynamics of lornoxicam account for its high efficacy and safety. Its analgesic effect is similar or superior to most NSAIDs (diclofenac, ibuprofen, indomethacin etc.). Unlike other analgesics, lornoxicam is a potent anti-inflammatory agent. In addition, its tolerability is superior to other nonselective NSAIDs. Lornoxicam can be prescribed by different specialists to reduce pain of any origin regardless of its severity. Good safety profile and anti-inflammatory activity allow to use this agent for many inflammatory and degenerative disorders of musculoskeletal system. Various formulations of lornoxicam improve adherence to treatment.

Key words: non-steroidal anti-inflammatory drugs, lornoxicam, analgesia, anti-inflammatory effect, fever, cyclooxygenase, selectivity, prostaglandins, osteoarthritis, rheumatoid arthritis, gastropathy, comorbidity.

For citation: Klimova O.Yu., Berdnikova N.G., Zhuravleva M.V. Analgesic and anti-inflammatory effects of lornoxicam: efficacy and safety // RMJ. 2016. № 25. P.1676 –1682.