What hides the so-called diagnosis of «dysautonomia»?
E.V. Ekusheva1, V.B. Voitenkov1,2
1 Institution of Advanced Training of Federal Medical and Biological Agency, Moscow
2 Research and Clinical Center of Infectious Diseases for Children of Federal Medical and Biological Agency, Saint Petersburg
It is known that the autonomic nervous system (ANS) is of great importance for the functioning of the whole organism and the regulation of its individual physiological processes. In the overwhelming majority of cases, autonomic disorders are secondary and occur in many neurological, mental, somatic diseases and psychogenic disorders. In local clinical practice, specialists of different profiles often and widely set diagnoses «angioneurosis» (D) or «autonomic dysfunction», representing in most cases psychogenically caused polysystemic disorders. Emotional-affective disorders of varying severity almost obligately accompany autonomic dysfunction, the leading ones are anxiety disorders of varying severity: from fairly mild forms in patients with AD to extremely severe disabling conditions that can be fatal. Treatment of patients with AD consists of complex pharmacological and non-drug approaches. One of the new generation drugs with combined anxiolytic, nootropic, antiasthenic and other effects recommended for the treatment of mild anxiety disorders or used in the complex therapy of affective disorders of varying severity is Tenoten, containing ultra-low doses of affinity purified antibodies to the brain-specific protein S-100.
Key words: dysautonomia, psychogenic disorders, anxiety disorders, Tenoten.
For citation: Ekusheva E.V., Voitenkov V.B. What hides the so-called diagnosis of «dysautonomia»? // RMJ. Medical Review. 2018. № 9. P.46 –50.
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4. Воробьева О.В. Вегетативная дисфункция, ассоциированная с тревожными расстройствами // Эффективная фармакотерапия. 2011. Т. 17. С. 46–50 [Vorobieva O.V. Vegetativnayadisfunkciya, associirovannaya s trevozhnimi rasstroistvami // Effektivnaya farmakoterapiya. 2011. Vol. 17. P. 46–50. (in Russian)].
5. Gilkey D.P., Keefe T.J., Peel J.L., Kassab O.M. Risk factors associated with back pain: cross-sectional study of 963 college students // J Manipulative Physiol Ther. 2010. Vol. 33. P. 88–95.
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8. Wessely S., Nimnuan C., Sharpe M. Functional somatic syndromes: one or many? // Lancet. 1999. Vol. 354. P. 936–939.
9. Fink P., Toft T., Hansen M.S., Ornbol E. Symptoms and syndromes of bodily distress: an exploratory study of 978 internal medical, neurological, and primary care patients // Psychosomatic Medicine. 2007. Vol. 69. P. 30–39.
10. Азимова Ю.Э., Сергеев А.В., Осипова В.В., Табеева Г.Р. Диагностика и лечение головных болей в России: результаты анкетного опроса врачей // Российский журнал боли. 2011. № 3-4. С. 12–17 [Azimova Yu.E., Sergeev A.V., Osipova V.V., Tabeeva G.R. Diagnostika I lecheniye golovnih boley v Rossii: rezultati anketnogo oprosa vrachey // Russian Journal of Pain. 2011. № 3-4. P. 12–17 (in Russian)].
11. Тарасова С.Н., Амелин А.В., Скоромец А.А. Распространенность и выявляемость первичных и симптоматических форм хронической ежедневной головной боли // Казанский медицинский журнал. 2008. Т. 89. С. 427–431 [Tarasova S.N., Amelin A.V., Skoromets A.A. Rasprostranennost I viyavlaemost pervichnih I simptomaticheskih form hronicheskoy ezhegodnoy golovnoy boli // Kazanskiy Medicinskiy Zhurnal. 2008. Vol. 89. P. 427–431. (in Russian)].
12. Teismann T.,Lukaschek T., Hiller T.S. Suicidal ideation in primary care patients suffering from panic disorder with or without agoraphobia // BMC Psychiatry. 2018. Vol. 18. P. 305.
13. Lerman S.F., Zvia R., Brill S., Hadar S. Longitudinal associations between depression, anxiety, pain, and pain-related disability in chronic pain patients // Psychosomatic Medicine. 2015. Vol. 77. P. 333–341.
14. Ferro M.A. Major depressive disorder, suicidal behaviour, bipolar disorder, and generalized anxiety disorder among emerging adults with and without chronic health conditions // Epidemiologic Psychiatric Sciences. 2016. Vol. 25. P. 462–474.
15. De Heer E.W., Gerrits M.M.J.G., Beekman A.T.F. The Association of Depression and Anxiety with Pain: A Study from NESDA. // PLoS One. 2014. Vol. 9. e106907.
16. Demyttenaere K., Bruffaerts R., Lee S., Posada-Villa J. Mental disorders among persons with chronic back or neck pain: results from the World Mental Health Surveys // Pain. 2007. Vol. 129. P. 332–342.
17. Gureje O., Von Korff M., Kola L., Demyttenaere K. The relation between multiple pains and mental disorders: results from the World Mental Health Surveys // Pain. 2008. Vol. 135. P. 82–91.
18. Vlaeyen J.W., Linton S.J. Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art // Pain. 2000. Vol. 85. P. 317–332.
19. Asmundson G.J., Katz J. Understanding the co-occurrence of anxiety disorders and chronic pain: state-of-the-art // Depressian and Anxiety. 2009. Vol. 26. P. 888–901.
20. Shanahan L., Zucker N., Copeland W.E., Bondy C.L. Childhood somatic complaints predict generalized anxiety and depressive disorders during young adulthood in a community sample // Psychology Medicine. 2015. Vol. 45. P. 1721–1730.
21. Noel M., Groenewald C.B., Beals-Erickson S.E., Gebert J.T. Chronic pain in adolescence and internalizing mental health disorders: A nationally representative study // Pain. 2016. Vol. 157. P. 1333–1338.
22. Means-Christensen A.J., Roy-Byrne P.P., Sherbourne C.D., Craske M.G. Relationships among pain, anxiety, and depression in primary care // Depression and Anxiety. 2008. Vol. 25. P. 593–600.
23. Ayuso Mateos J.L., Bayon Perez C., Santo-Domingo Carrasco J., Olivares D. Atypical chest pain and panic disorder // Psychotherapy and Psychosomatic.1989. Vol. 52. P. 92–95.
24. Ossipov M.H., Dussor G.O., Porreca F. Central modulation of pain // Journal of Clinical Investigations. 2010. Vol.120. P. 3779–3787.
25. Millan M.J. Descending control of pain // Progress in Neurobiology.2002. Vol. 66. P. 355–474.
26. Bryant C., Jackson H., Ames D. The prevalence of anxiety in older adults: methodological issues and a review of the literature // Journal of Affective Disorders. 2008. Vol. 109(3). P. 233–250.
27. Wolitzky-Taylor K.B., Castriotta N., Lenze E.J., Stanley M.A. Anxiety disorders in older adults: a comprehensive review // Depression and Anxiety. 2010. Vol. 27(2). P. 190-211.
28. Diefenbach G.J., Hopko D.R., Feigon S., Stanley M.A. ‘Minor GAD’: characteristics of subsyndromal GAD in older adults // Behavioral Research and Therapy. 2003. Vol.41(4). P. 481-487.
29. Costello E.J., Mustillo S., Erkanli A., Keeler G. Prevalence and development of psychiatric disorders in childhood and adolescence // Archives of General Psychiatry. 2003. Vol.60. P. 837–844. 30. Cole D.A., Peeke L.G., Martin J.M., Truglio R. A longitudinal look at the relation between depression and anxiety in children and adolescents // Journal of Consulting and Clinical Psychology. 1998. Vol.66. P. 451–460.
31. Fearon P., Hotopf M. Relation between headache in childhood and physical and psychiatric symptoms in adulthood: National birth cohort study // British Medical Journal. 2001. Vol.322. P.1145.
32. Wetherell J.L., Thorp S.R., Patterson T.L. Quality of life in geriatric generalized anxiety disorder: a preliminary investigation //Journal of Psychiatric Research. 2004. Vol. 38. P. 305–312.
33. Massion A.O., Warshaw M.G., Keller M.B. Quality of life and psychiatric morbidity in panic disorder and generalized anxiety disorder // American Journal of Psychiatry. 1993. Vol.150. P. 600–607.
34. Wittchen H.U. Generalized anxiety disorder: prevalence, burden, and cost to society // Depression and Anxiety. 2002. Vol.16. P.162–171.
35. Bernal M., Haro J.M., Bernert S., Brugha T. Risk factors for suicidality in Europe: results from the ESEMED study // Journal of Affective Disorders. 2007. Vol.101. P. 27–34.
36. Kanwar A., Prokop L.J., Sim L.A., Feldstein D. The association between anxiety disorders and suicidal beh * avior: a systematic review and meta-analysis // Depression and Anxiety. 2013. Vol.30. P. 917–929.
37. Шавловская О.А. Комплексная терапия тревожных состояний у больных соматического профиля // Consilium medicum. 2017. Т. 19. №2. С. 41–44. [Shavlovskaya O.A. Kompleksnaya terapiya trevozhnih sostoyaniy u bolnih somaticheskogo profilya // Consilium Medicum. 2017. Vol.19(22). P.41–44. (in Russian)].
38. ТенатенТенотен: инструкция по применению. https://www.rlsnet.ru/tn_index_id_33140.htm. [TenatenTenoten: instrukciya po primeneniyu. https://www.rlsnet.ru/tn_index_id_33140.htm. (in Russian)].
39. Buschert J., Hohoff C., Touma C. et al. S100B overexpression increases behavioral and neural plasticity in response to the social environment during adolescence // Journal of Psychiatric Research. 2013. Vol. 47 (11). P. 791–799.
40. Pankratova S., Klingelhofer J., Dmytriyeva O. et al. The S100A4 protein signals through the ErbB4 receptor to promote neuronal survival // Theranostics. 2018. Vol. 1;8(14). Р. 3977–3990.
41. Kardash E.V., Ertuzun I.A., Khakimova G.R. et al. Dose-response effect of antibodies to S100 protein and cannabinoid receptor type 1 in released-active form in the light-dark test in mice // Dose Response.2018. Vol.16(2). Р.1559325818779752.
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