Current possibilities of an allergy laboratory diagnosis

A.M. Bala, A.B. Kleschenko, Yu.V. Chursinova

Moscow Regional Scientific Research Clinical Institute named after M.F. Vladimirskiy

Allergic diseases are a global epidemiological problem: 10–30% of the planet population has any allergic diseases’ manifestations. In this regard, early diagnosis and prevention of allergic diseases are extremely relevant. Current allergy diagnosis is a wide range of effective tools that allow maximally personalizing the diagnosis and predicting treatment effectiveness. Mainly, IgE are involved in allergic reactions development, as they are responsible for the manifestation of immediate-type allergy and are detected by using various diagnostic tools.
Polysensitization is an important clinical characteristic, as it affects about 70–80% of the world’s allergic population. The diagnostic pathway requires an adequate and detailed methodology based on the compliance demonstration of medical history with documented sensitization. The patient management with polysensitization should rely on a careful examination, mainly, based on the possibilities of allergy molecular diagnostics. Multiplex systems are the most breakthrough method, which gives a complete sensitization profile picture (a key aspect of the allergic diseases’ diagnosis).

Keywords: allergic diseases, IgE, allergy diagnosis, polysensitization, biochip, component diagnosis, molecular diagnostics, ACIT.
For citation: Bala A.M., Kleschenko A.B., Chursinova Yu.V. Current possibilities of an allergy laboratory diagnosis. RMJ. 2019;1(II):56–61.