Uncontrolled course of respiratory allergic diseases in pregnant women
DOI: 10.32364/2618-8430-2022-5-2-122-128
A.A. Paschenko1, Yu.E. Dobrokhotova1, D.S. Fomina2,3, M.G. Pashchenko4
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2City Clinical Hospital No. 52, Moscow, Russian Federation
3I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
4P.V. Mandryka Central Military Clinical Hospital, Moscow, Russian Federation
The article presents the analysis of literature data on the pathogenesis, course and pharmacotherapy in pregnancy during respiratory allergic diseases. The article also considers the systematized ARIA recommendations (Updated 2020) on the diagnosis and pharmacotherapy of allergic rhinitis (AR) in pregnancy, differential diagnosis concerning nasal breathing disorders of atopic and non-atopic etiology during gestation, and the developed therapeutic methods for the patient management (in particular, pregnant women) with an allergic phenotype (a combination of asthma with allergic rhinitis and/or atopic dermatitis). The association between the uncontrolled course of allergic rhinitis in pregnant women and the risk of the bronchial asthma onset has been proven. Of utmost importance, for improving perinatal outcomes is the optimization of therapy and symptom control of allergic diseases during pregnancy in the interdisciplinary practice of an obstetrician-g ynecologist and allergist/immunologist. AR in pregnancy should be differentiated from the most common form of nasal breathing disorders in pregnant women — vasomotor rhinitis. Severe uncontrolled vasomotor rhinitis in pregnant women, as an individual nosological form, can worsen the existing AR and bronchial asthma course. The authors present a mathod for the AR step therapy based on pharmacological characteristics and safety profile of drugs in pregnancy.
Keywords: allergic rhinitis, bronchial asthma, pregnancy, vasomotor rhinitis of pregnant women, pharmacotherapy, obstetric complications.
For citation: Paschenko A.A., Dobrokhotova Yu.E., Fomina D.S., Pashchenko M.G. Uncontrolled course of respiratory allergic diseases in pregnant women. Russian Journal of Woman and Child Health. 2022;5(2):122–128 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-122-128.
About the authors:
Alexander A. Pashchenko — postgraduate student of the Department of Obstetrics and Gynecology of the Medical Faculty, Pirogov Russian National Research Medical University; 1 Ostrovityanov str., Moscow, 117997, Russian Federation; ORCID iD 0000-0003-0202-2740.
Yulia E. Dobrokhotova — Dr. Sc. (Med.), Professor, Head of the Department of Obstetrics and Gynecology of the Medical Faculty, Pirogov Russian National Research Medical University; 1 Ostrovityanov str., Moscow, 117997, Russian Federation; ORCID iD 0000-0002-7830-2290.
Daria S. Fomina — C. Sc. (Med.), Associate Professor of the Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 bldn. 2 Trubetskaya str., Moscow, 119992, Russian Federation; Head of the Moscow City Scientific and Practical Center of Allergology and Immunology at the City Clinical Hospital No. 52; 3 Pekhotnaya str., Moscow, 123182, Russian Federation; ORCID iD 0000-0002-5083-6637.
Marina G. Paschenko — allergist-immunologist, Head of the allergological office of the Medical Center for Premorbid and Emergency Conditions at the P.V. Mandryka Central Military Clinical Hospital; 8A Bolshaya Olenya str., Moscow, 107014, Russian Federation; ORCID iD 0000-0003-1303-5686.
Contact information: Alexander A. Pashchenko, e-mail: al.paschenko2018@gmail.com.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 17.02.2022.
Revised 17.03.2022.
Accepted 11.04.2022.
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