Hereditary angioedema: case report
DOI: 10.32364/2587-6821-2020-4-1-58-61
E.V. Andronova1, E.K. Bel’tyukov2, T.S. Lepeshkova2,3
1LLC “Family doctor”, Magnitogorsk, Russian Federation
2Ural State Medical University, Yekaterinburg, Russian Federation
3Children’s City Polyclinic No. 13, Yekaterinburg, Russian Federation
Despite the awareness of doctors, hereditary angioedema is still an important issue both in children and adults being often masqueraded by other diseases. Recurrent episodes of potentially life-threatening skin, mucosal, and submucosal edema can be fatal. This paper describes case report which demonstrates the diversity of clinical signs of angioedema. These signs illustrate various localization of angioedema while being the symptoms of other diseases (i.e., hay fever, pyelonephritis, cystitis etc.). Careful history taking and analysis of objective data help define key signs of hereditary angioedema, early diagnose and verify the disease (by measuring concentration and activity of C1 esterase inhibitor), and perform genetic testing in patients and their relatives. Early diagnosis and adequate treatment with icatibant (Firazyr) and C1 esterase inhibitor prevent fatal outcome and significantly improve the quality of life of patients with hereditary angioedema.
Keywords: hereditary angioedema, atopy, abdominal attack, complement defect, bradykinin, icatibant, C1 esterase inhibitor.
For citation: Andronova E.V., Bel’tyukov E.K., Lepeshkova T.S. Hereditary angioedema: case report. Russian Medical Review. 2020;4(1):58–61. DOI: 10.32364/2587-6821-2020-4-1-58-61.
About the authors:
1Elena V. Andronova — MD, allergist and immunologist,
ORCID iD 0000-0002-9506-6365;
2Evgeniy K. Bel’tyukov — MD, PhD, Professor of the Department of Faculty Therapy, Endocrinology, Allergy, and Immunology, ORCID iD 0000-0003-2485-2243;
2,3Tat’yana S. Lepeshkova — MD, PhD, Assistant of the Department of Polyclinic Pediatrics and Pediatrics, allergist and immunologist, ORCID iD 0000-0002-0716-3529.
1LLC “Family doctor”. 11, Zhukova str., Magnitogorsk, 455034, Russian Federation.
2Ural State Medical University. 3, Repin str., Yekaterinburg, 620028, Russian Federation.
3Children’s City Polyclinic No. 13. 16a, Tkachey str., Yekaterinburg, 620100, Russian Federation.
Contact information: Elena V. Andronova, e-mail:
andronova.elena_@mail.ru. Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 21.02.2020.
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