Clinical efficacy of basic anti-inflammatory therapy for allergic rhinitis in children
DOI: 10.32364/2587-6821-2020-4-1-15-18
R.M. Fayzullina1, Z.A. Shangareeva1, A.V. Sannikova1, Zh.A. Valeeva2, S.M. Popova2
1Bashkir State Medical University, Ufa, Russian Federation
2City Children’s Clinical Hospital No. 17, Ufa, Russian Federation
Aim: to assess clinical efficacy of basic anti-inflammatory therapy with mometasone furoate (Nosefrin®) for allergic rhinitis (AR) in children.
Patients and Methods: 67 children aged 4–17 years (33 boys, 49.25% and 34 girls, 50.75%) who were followed-up in day care unit of the City Children’s Clinical Hospital (Ufa) in November-December 2019 were enrolled in the study. Anamnesis, clinical data, results of the survey of children with the exacerbation of persistent AR, personal child health records (form 112/u), and results of parent surveys on disease course, outpatient management before referral, and laboratory and instrumental tests were analyzed. All children underwent general examination, laboratory and instrumental tests. During the first visit, all children were prescribed with one dose of mometasone furoate nasal spray/Nosefrin® (50 μg in each nostril once a day). To assess treatment efficacy, the survey was performed at baseline and after 1 and 4 weeks of the treatment.
Results: as early as after 1 week of the treatment, main symptoms of AR (i.e., nasal congestion, rhinorrhea, itching, and sneezing) have significantly improved (χ2=62.5676, р=0.0005). After 4 weeks of the treatment, the quality of life (χ2=35.2941, р=0.0005) and sleep disorders (χ2=48.8498, р=0.0005) have significantly improved while the need for decongestants has significantly reduced (χ2=55.5036, р=0.0005).
Conclusion: considering good clinical efficacy and safety profile, mometasone furoate (Nosefrin®) can be recommended as basic therapy for AR in children.
Keywords: allergic rhinitis, children, basic therapy, anti-inflammatory treatment, glucocorticosteroids, efficacy, safety.
For citation: Fayzullina R.M., Shangareeva Z.A., Sannikova A.V. et al. Clinical efficacy of basic anti-inflammatory therapy for allergic rhinitis in children. Russian Medical Review. 2020;4(1):15–18. DOI: 10.32364/2587-6821-2020-4-1-15-18.
About the authors:
1Rezeda M. Fayzullina — MD, PhD, Professor of the Department, ORCID iD 0000-0002-9001-1437;
1Ziliya A. Shangareeva — MD, PhD, Associate Professor of the Department, ORCID iD 0000-0001-8745-9989;
1Anna V. Sannikova — MD, PhD, Associate Professor of the Department, ORCID iD 0000-0002-1207-8134;
2Zhanna A. Valeeva — MD, PhD, Deputy Head Doctor for Polyclinics, ORCID iD 0000-0001-8567-2671;
2Svetlana M. Popova — MD, Head of Day Care Unit, ORCID iD 0000-0003-4199-8332.
1Bashkir State Medical University, Department of Faculty Pediatrics with the Course of Pediatrics, Neonatology, and Simulation Center of the Institute of Additional Professional Education. 3, Lenin str., Ufa, 450000, Russian Federation.
2City Children’s Clinical Hospital No. 17. 29, Svobody str., Ufa, 450065, Russian Federation.
Contact information: Rezeda M. Fayzullina, e-mail: fayzullina@yandex.ru. Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 04.02.2020.
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