The role of bacterial endotoxin in pathogenesis of preeclampsia
DOI: 10.32364/2618-8430-2025-8-2-2
I.G. Mustafin1, T.E. Kurmanbaev2, E.Yu. Yupatov3, R.M. Nabiullina1, N.A. Safina1, Z.R. Mukhametzyanova1, V.V. Gurinovich2, A.N. Sachenok2, Z.V. Azhgirei2
1Kazan State Medical University, Kazan, Russian Federation, Kazan, Russian Federation
2Military Medical Academy, St. Petersburg, Russian Federation
3Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation
Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Despite a great number of studies, pathogenesis of PE is underinvestigated. However, according to recent data, insufficient remodeling of spiral arteries, oxidative stress, maternal vascular endothelial dysfunction and systemic inflammation are of the greatest importance in PE pathogenesis. Previously, it was believed that abnormal placentation plays an exceptional role in pathogenesis of PE, but now the fact is challenged by many authors. The transcriptomic studies showed that a significant number of genes regulating completely different processes (e.g., blood pressure, apoptosis, fetal growth and development, hormone secretion, metabolism, homeostasis and cellular transmission) are involved in PE development. Moreover, a relationship was found between PE and insulin resistance. Thus, it is more correct to consider PE as a multisystem disease associated with state of a macroorganism. The paper highlights a role of a lipopolysaccharide of gram-negative microorganisms in pathogenesis of PE.
Keywords: preeclampsia, pathogenesis, endotoxin, lipopolysaccharide, systemic inflammatory response.
For citation: Mustafin I.G., Kurmanbaev T.E., Yupatov E.Yu., Nabiullina R.M., Safina N.A., Mukhametzyanova Z.R., Gurinovich V.V., Sachenok A.N., Azhgirei Z.V. The role of bacterial endotoxin in pathogenesis of preeclampsia. Russian Journal of Woman and Child Health. 2025;8(2):100–105 (in Russ.). DOI: 10.32364/2618-8430-2025-8-2-2
ABOUT THE AUTHORS:
Il'shat G. Mustafin — Dr. Sc. (Med.), Professor, Head of the Department of Biochemistry and Clinical Laboratory
Diagnosis, Kazan State Medical University; 49, Butlerov str., Kazan, 420012, Russian Federation; ORCID iD 0000-0001-9683-3012
Timur E. Kurmanbaev — C. Sc. (Med.), Senior Teacher at the Department of Obstetrics and Gynecology, Military Medical Academy; 6Zh, Academician Lebedev str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0003-0644-5767
Evgenyi Yu. Yupatov — Dr. Sc. (Med.), Assistant Professor, Head of the Department of Obstetrics and Gynecology, Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education; 11, Mushtari str., Kazan, 420012, Russian Federation; ORCID iD 0000-0001-8945-8912
Roza M. Nabiullina — C. Sc. (Med.), Assistant Professor of the Department of Biochemistry and Clinical Laboratory Diagnosis, Kazan State Medical University; 49, Butlerov str., Kazan, 420012, Russian Federation; ORCID iD 0000-0001-5942-5335
Nelly A. Safina — C. Sc. (Biol.), Teaching Assistant at the Department of Biochemistry and Clinical Laboratory Diagnosis, Kazan State Medical University; 49, Butlerov str., Kazan, 420012, Russian Federation; ORCID iD 0000-0002-2231-3716
Zarina R. Mukhametzyanova — Postgraduate Student, Department of Biochemistry and Clinical Laboratory Diagnosis, Kazan State Medical University; 49, Butlerov str., Kazan, 420012, Russian Federation; ORCID iD 0000-0002-7525-7455
Vladlen V. Gurinovich — 6th Year Military Student of the Special Faculty, Military Medical Academy; 6Zh, Academician Lebedev str., St. Petersburg, 194044, Russian Federation; ORCID iD 0009-0005-0113-0178
Alexey N. Sachenok — 6th Year Military Student of the Special Faculty, Military Medical Academy; 6Zh, Academician Lebedev str., St. Petersburg, 194044, Russian Federation; ORCID iD 0009-0006-0556-8684
Zakhar V. Azhgirey — 6th Year Military Student of the Special Faculty, Military Medical Academy; 6Zh, Academician Lebedev str., St. Petersburg, 194044, Russian Federation; ORCID iD 0009-0004-2593-8465
Contact information: Timur E. Kurmanbaev, e-mail: timka_rus@inbox.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 04.03.2025.
Revised 27.03.2025.
Accepted 21.04.2025.
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