DOI: 10.32364/2618-8430-2020-3-2-77-82
Antenatal micronutrient support is essential for a healthy child
E.I. Borovkova1, A.L. Zaplatnikov2, E.D. Zhdakaeva2
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Adequate intake of macro- and microelements during pregnancy meets the growing needs of a female organism and lays the basis for a child’s health. According to the World Health Organization, in malnutrition or chronic health conditions (i. e. gastrointestinal disorders, diabetes, hypothyroidism etc.) in a pregnant woman, additional intake of essential micronutrients is required. Cochrane Reviews demonstrate that multivitamin supplements reduce the occurrence of intrauterine growth restriction and low birthweight. Zinc is a microelement whose adequate intake is of crucial importance. Mild zinc deficiency manifests as recurrent respiratory infections, taste and smell loss, night blindness, impaired spermatogenesis, and (sometimes) mild psoriasis-like dermatitis. Severe zinc deficiency is characterized by more often respiratory infections and more severe skin conditions (e. g., acrodermatitis with erythematous, squamous, vesicular bullous, or pust ular rash in perioral and perianal areas), alopecia, persistent diarrhea, stomatitis, and glossitis, growth and developmental delay, and various psychoneurological disorders.
Keywords: pregnancy, newborn, infant, vitamin mineral supplement, microelements, zinc, atopic dermatitis, deficiency.
For citation: Borovkova E.I., Zaplatnikov A.L., Zhdakaeva E.D. Antenatal micronutrient support is essential for a healthy child. Russian Journal of Woman and Child Health. 2020;3(2):77–82. DOI: 10.32364/2618-8430-2020-3-2-77-82.
References
1. Ramakrishnan U., Grant F., Goldenberg T. et al. Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol 2012; 26(Suppl 1):285–301. DOI: 10.1111/j.1365-3016.2012.01281.x.
2. Barker D.J., Thornburg K.L. The obstetric origins of health for a lifetime. Clin Obstet Gynecol. 2013;56(3):511–519. DOI: 10.1097/GRF.0b013e31829cb9ca.
3. Roseboom T., de Rooij S., Painter R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev. 2006;82(8):485–491. DOI: 10.1016/j.earlhumdev.2006.07.001.
4. Institute of Medicine: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. (Elestronic resource). URL: https://www.nap.edu/catalog/10026/dietary-reference-intakes-for-vitamin-a-vitamin-k-arsenic-boron-chromium-copper-iodine-iron-manganese-molybdenum-nickel-silicon-vanadium-and-zinc. Access date: 04.03.2020.
5. Academy of Nutrition and Dietetics. Practice Paper of the Academy of Nutrition and Dietetics Abstract: Nutrition and Lifestyle for a Healthy Pregnancy Outcome 2014. (Elestronic resource). URL: http://www.eatright.org/members/practicepapers. Access date: 23.03.2020.
6. WHO recommendations on antenatal care for a positive pregnancy experience. WHO; 2016. (Elestronic resource). URL: https://apps.who.int/iris/bitstream/handle/10665/250796/9789241549912-eng.pdf;jsessionid=B0B92BF4755844235E4C5C7567AAB427?sequence=1. Access date: 23.03.2020.
7. Keats E.C., Tam E., Haider B.A., Bhutta Z.A. Multiple‐micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019;3(3):CD004905. DOI: 10.1002/14651858.CD004905.pub6.
8. King J.C., Shames D.M., Woodhouse L.R. Zinc homeostasis in humans. J Nutr. 2000;130(Suppl. 5):1360–1366. DOI: 10.1093/jn/130.5.1360S.
9. Krebs N.E., Hambidge K.M. Zinc metabolism and homeostasis: the application of tracer techniques to human zinc physiology. Biometals. 2001;14(3–4):397–412. DOI: 10.1023/A:1012942409274.
10. Skal’niy A.V. Zinc and human health. Orenburg: RICK GOU OGE; 2003 (in Russ.).
11. Brown K.H., Rivera J.A., Bhutta Z. et al. International Zinc Nutrition Consultative Group (IZiNCG) technical document No. 1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull. 2004;25(1 Suppl 2):S99–203. PMID: 18046856.
12. Florea D.I., Lуpez J.M., Millen E. et al. We and zinc. Nutr. Hosp. 2012;27(3):691–700. DOI: 10.3305/nh.2012.27.3.5697.
13. Sheybak V.M. The biological significance and regulation of zinc homeostasis in mammals. Problemy zdorov’ya i ekologii. 2014;6:11–17 (in Russ.).
14. Kudrin A.V., Skalniy A.V., Zhavoronkov A.A. et al. Immunopharmacology of trace elements. M.: KMK; 2000 (in Russ.).
15. Rink L., Gabriel P. Zinc and the immune system. Proc Nutr Soc. 2000;59:541–552. DOI: 10.1017/S0029665100000781.
16. Kabu K., Yamasaki S., Kamimura S. et al. Zinc is required for Fc epsilon RI-mediated mast cell activation. J Immunol. 2006;177:1296–1305. DOI: 10.4049/jimmunol.177.2.1296.
17. Aydemir T.B., Blanchard R.K., Cousins R.J. Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations. Proc Natl Aca Sci. USA. 2006;103:1699–1704. DOI: 10.1073/pnas.0510407103.
18. Hodkinson C.F., Kelly M., Alexander H.D. et al. Effect of zinc supplementation on the immune status of healthy older individuals aged 55–70 years: the ZENITH study. J Gerontol A Biol Sci. Med. Sci. 2007;62:598–608. DOI: 10.1093/gerona/62.6.598.
19. Intorre F., Polito A., Andriollo-Sanchez M. et al. Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. Eur J Clin Nutr. 2008;62:1215–1223. DOI: 10.1038/sj.ejcn.1602844.
20. Karzakova L.M., Ukhterova N.D., Borisova L.V., Ivanov L.N. Immunological and immunogenetic markers of chronic obstructive pulmonary disease in conditions of natural zinc deficiency. Meditsinskaya immunologiya. 2008;10(6):513–518 (in Russ.).
21. Institute of Medicine. Dietary reference intakes: The essential guide to nutrient requirements. National Academies Press, Washington, DC; 2006.
22. Jen M., Yan A.C. Syndromes associated with nutritional deficiency and excess. Clin Dermatol. 2010;28(6):669–685. DOI: 10.1016/j.clindermatol.2010.03.029.
23. Studenikin V.M., Tursunkhuzhayeva S.Sh., Shelkovsky V.I. Zinc in neuropediatrics and neurodietology. Lechashchiy vrach. 2012;1:44–47 (in Russ.).
24. Khaliullina S.V. The clinical significance of zinc deficiency in the body of a child. Vestnik sovremennoy klinicheskoy meditsiny. 2013;6(3):73–76 (in Russ.). DOI: 10.20969/VSKM.2013.6(3).72-78.
25. Hambidge K.M., Krebs N.F. Zinc deficiency: a special challenge. J Nutr. 2007;137:1101–1105. DOI: 10.1093/jn/137.4.1101.
26. King J.C., Cousins R.J. Zinc. In: Modern Nutrition in Health and Disease, 11th. Ross A.C., Caballero B., Cousins R.J. et al. (Eds). Lippincott Williams and Wilkins, Philadelphia; 2014.
27. Ota E., Mori R., Middleton P. et al. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database of Systematic Reviews. 2015;2:CD000230. DOI:10.1002/14651858.CD000230.pub5.
28. Aumeistere L., Ciproviča I., Zavadska D. et al. Zinc Content in Breast Milk and Its Association with Maternal Diet. Nutrients. 2018;10(10):1438. DOI: 10.3390/nu10101438.
29. Watson L., Cartwright D., Jardine L.A. et al. Transient neonatal zinc deficiency in exclusively breastfed preterm infants. J Paediatr Child Health. 2018;54(3):319–322. DOI: 10.1111/jpc.13780.
30. Centers for Disease Control and Prevention (CDC). Notes from the field: Zinc deficiency dermatitis in cholestatic extremely premature infants after a nationwide shortage of injectable zinc — Washington, DC, December 2012. MMWR Morb Mortal Wkly Rep. 2013;62(7):136–137. PMID: 23425963.
31. Iannotti L.L., Zavaleta N., León Z. et al. Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants. J Pediatr. 2010;156:960–964. DOI: 10.1016/j.jpeds.2009.12.023.
32. Osendarp S.J., van Raaij J.M., Darmstadt G.L. et al. Zinc supplementation during pregnancy and effects on growth and morbidity in low birthweight infants: a randomised placebo controlled trial. Lancet. 2001;357(9262):1080–1085. DOI: 10.1016/s0140-6736(00)04260-4.
33. Totochia N.E., Beketova N.A., Konovalova L.S. et al. The effect of providing women with vitamins during pregnancy. Voprosy detskoy diyetologii. 2011;9(3):2–5 (in Russ.).
34. Dobrokhotova Yu.E., Borovkova E.I. Pregravid preparation: goals, objectives, opportunities. Effektivnaya farmakoterapiya. 2017;1:14–18 (in Russ.).
35. Das J.K., Salam R.A., Mahmood S.B. et al. Food fortification with multiple micronutrients: impact on health outcomes in general population. Cochrane Database Syst Rev. 2019;12:CD011400. DOI: 10.1002/14651858.CD011400.pub2.
36. Ota E., Tobe-Gai R., Mori R., Farrar D. Antenatal dietary advice and supplementation to increase energy and protein intake. Cochrane Database Syst Rev. 2012;(9):CD000032. DOI: 10.1002/14651858.CD000032.pub2.
37. Abu-Saad K., Fraser D. Maternal nutrition and birth outcomes. Epidemiol Rev. 2010; 2010;32:5–25. DOI: 10.1093/epirev/mxq001.
38. Vitamin supplementation in pregnancy. Drug Ther Bull Drug Ther Bull. 2016;54(7):81–84. DOI: 10.1136/dtb.2016.7.0414.
39. Savchenko T.N., Dergacheva I.A., Agaeva M.I. Micronutrients and pregnancy. RMJ. 2016;15:1005–1008 (in Russ.).
40. Legon’kova T.I., Shtykova O.N., Voytenkova O.V., Stepina T.G. Clinical significance of zinc: Results of prospective observation of children for 14 years. Meditsinskiy sovet. 2018;11:147–154 (in Russ.).
41. Vitrum® Prenatal Plus — instructions for use. (Electronic resource). URL: https://www.vidal.ru/drugs/vitrum-prenatal-plus. Access date: 28.04.2020 (in Russ.).
2. Barker D.J., Thornburg K.L. The obstetric origins of health for a lifetime. Clin Obstet Gynecol. 2013;56(3):511–519. DOI: 10.1097/GRF.0b013e31829cb9ca.
3. Roseboom T., de Rooij S., Painter R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev. 2006;82(8):485–491. DOI: 10.1016/j.earlhumdev.2006.07.001.
4. Institute of Medicine: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. (Elestronic resource). URL: https://www.nap.edu/catalog/10026/dietary-reference-intakes-for-vitamin-a-vitamin-k-arsenic-boron-chromium-copper-iodine-iron-manganese-molybdenum-nickel-silicon-vanadium-and-zinc. Access date: 04.03.2020.
5. Academy of Nutrition and Dietetics. Practice Paper of the Academy of Nutrition and Dietetics Abstract: Nutrition and Lifestyle for a Healthy Pregnancy Outcome 2014. (Elestronic resource). URL: http://www.eatright.org/members/practicepapers. Access date: 23.03.2020.
6. WHO recommendations on antenatal care for a positive pregnancy experience. WHO; 2016. (Elestronic resource). URL: https://apps.who.int/iris/bitstream/handle/10665/250796/9789241549912-eng.pdf;jsessionid=B0B92BF4755844235E4C5C7567AAB427?sequence=1. Access date: 23.03.2020.
7. Keats E.C., Tam E., Haider B.A., Bhutta Z.A. Multiple‐micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019;3(3):CD004905. DOI: 10.1002/14651858.CD004905.pub6.
8. King J.C., Shames D.M., Woodhouse L.R. Zinc homeostasis in humans. J Nutr. 2000;130(Suppl. 5):1360–1366. DOI: 10.1093/jn/130.5.1360S.
9. Krebs N.E., Hambidge K.M. Zinc metabolism and homeostasis: the application of tracer techniques to human zinc physiology. Biometals. 2001;14(3–4):397–412. DOI: 10.1023/A:1012942409274.
10. Skal’niy A.V. Zinc and human health. Orenburg: RICK GOU OGE; 2003 (in Russ.).
11. Brown K.H., Rivera J.A., Bhutta Z. et al. International Zinc Nutrition Consultative Group (IZiNCG) technical document No. 1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull. 2004;25(1 Suppl 2):S99–203. PMID: 18046856.
12. Florea D.I., Lуpez J.M., Millen E. et al. We and zinc. Nutr. Hosp. 2012;27(3):691–700. DOI: 10.3305/nh.2012.27.3.5697.
13. Sheybak V.M. The biological significance and regulation of zinc homeostasis in mammals. Problemy zdorov’ya i ekologii. 2014;6:11–17 (in Russ.).
14. Kudrin A.V., Skalniy A.V., Zhavoronkov A.A. et al. Immunopharmacology of trace elements. M.: KMK; 2000 (in Russ.).
15. Rink L., Gabriel P. Zinc and the immune system. Proc Nutr Soc. 2000;59:541–552. DOI: 10.1017/S0029665100000781.
16. Kabu K., Yamasaki S., Kamimura S. et al. Zinc is required for Fc epsilon RI-mediated mast cell activation. J Immunol. 2006;177:1296–1305. DOI: 10.4049/jimmunol.177.2.1296.
17. Aydemir T.B., Blanchard R.K., Cousins R.J. Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations. Proc Natl Aca Sci. USA. 2006;103:1699–1704. DOI: 10.1073/pnas.0510407103.
18. Hodkinson C.F., Kelly M., Alexander H.D. et al. Effect of zinc supplementation on the immune status of healthy older individuals aged 55–70 years: the ZENITH study. J Gerontol A Biol Sci. Med. Sci. 2007;62:598–608. DOI: 10.1093/gerona/62.6.598.
19. Intorre F., Polito A., Andriollo-Sanchez M. et al. Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. Eur J Clin Nutr. 2008;62:1215–1223. DOI: 10.1038/sj.ejcn.1602844.
20. Karzakova L.M., Ukhterova N.D., Borisova L.V., Ivanov L.N. Immunological and immunogenetic markers of chronic obstructive pulmonary disease in conditions of natural zinc deficiency. Meditsinskaya immunologiya. 2008;10(6):513–518 (in Russ.).
21. Institute of Medicine. Dietary reference intakes: The essential guide to nutrient requirements. National Academies Press, Washington, DC; 2006.
22. Jen M., Yan A.C. Syndromes associated with nutritional deficiency and excess. Clin Dermatol. 2010;28(6):669–685. DOI: 10.1016/j.clindermatol.2010.03.029.
23. Studenikin V.M., Tursunkhuzhayeva S.Sh., Shelkovsky V.I. Zinc in neuropediatrics and neurodietology. Lechashchiy vrach. 2012;1:44–47 (in Russ.).
24. Khaliullina S.V. The clinical significance of zinc deficiency in the body of a child. Vestnik sovremennoy klinicheskoy meditsiny. 2013;6(3):73–76 (in Russ.). DOI: 10.20969/VSKM.2013.6(3).72-78.
25. Hambidge K.M., Krebs N.F. Zinc deficiency: a special challenge. J Nutr. 2007;137:1101–1105. DOI: 10.1093/jn/137.4.1101.
26. King J.C., Cousins R.J. Zinc. In: Modern Nutrition in Health and Disease, 11th. Ross A.C., Caballero B., Cousins R.J. et al. (Eds). Lippincott Williams and Wilkins, Philadelphia; 2014.
27. Ota E., Mori R., Middleton P. et al. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database of Systematic Reviews. 2015;2:CD000230. DOI:10.1002/14651858.CD000230.pub5.
28. Aumeistere L., Ciproviča I., Zavadska D. et al. Zinc Content in Breast Milk and Its Association with Maternal Diet. Nutrients. 2018;10(10):1438. DOI: 10.3390/nu10101438.
29. Watson L., Cartwright D., Jardine L.A. et al. Transient neonatal zinc deficiency in exclusively breastfed preterm infants. J Paediatr Child Health. 2018;54(3):319–322. DOI: 10.1111/jpc.13780.
30. Centers for Disease Control and Prevention (CDC). Notes from the field: Zinc deficiency dermatitis in cholestatic extremely premature infants after a nationwide shortage of injectable zinc — Washington, DC, December 2012. MMWR Morb Mortal Wkly Rep. 2013;62(7):136–137. PMID: 23425963.
31. Iannotti L.L., Zavaleta N., León Z. et al. Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants. J Pediatr. 2010;156:960–964. DOI: 10.1016/j.jpeds.2009.12.023.
32. Osendarp S.J., van Raaij J.M., Darmstadt G.L. et al. Zinc supplementation during pregnancy and effects on growth and morbidity in low birthweight infants: a randomised placebo controlled trial. Lancet. 2001;357(9262):1080–1085. DOI: 10.1016/s0140-6736(00)04260-4.
33. Totochia N.E., Beketova N.A., Konovalova L.S. et al. The effect of providing women with vitamins during pregnancy. Voprosy detskoy diyetologii. 2011;9(3):2–5 (in Russ.).
34. Dobrokhotova Yu.E., Borovkova E.I. Pregravid preparation: goals, objectives, opportunities. Effektivnaya farmakoterapiya. 2017;1:14–18 (in Russ.).
35. Das J.K., Salam R.A., Mahmood S.B. et al. Food fortification with multiple micronutrients: impact on health outcomes in general population. Cochrane Database Syst Rev. 2019;12:CD011400. DOI: 10.1002/14651858.CD011400.pub2.
36. Ota E., Tobe-Gai R., Mori R., Farrar D. Antenatal dietary advice and supplementation to increase energy and protein intake. Cochrane Database Syst Rev. 2012;(9):CD000032. DOI: 10.1002/14651858.CD000032.pub2.
37. Abu-Saad K., Fraser D. Maternal nutrition and birth outcomes. Epidemiol Rev. 2010; 2010;32:5–25. DOI: 10.1093/epirev/mxq001.
38. Vitamin supplementation in pregnancy. Drug Ther Bull Drug Ther Bull. 2016;54(7):81–84. DOI: 10.1136/dtb.2016.7.0414.
39. Savchenko T.N., Dergacheva I.A., Agaeva M.I. Micronutrients and pregnancy. RMJ. 2016;15:1005–1008 (in Russ.).
40. Legon’kova T.I., Shtykova O.N., Voytenkova O.V., Stepina T.G. Clinical significance of zinc: Results of prospective observation of children for 14 years. Meditsinskiy sovet. 2018;11:147–154 (in Russ.).
41. Vitrum® Prenatal Plus — instructions for use. (Electronic resource). URL: https://www.vidal.ru/drugs/vitrum-prenatal-plus. Access date: 28.04.2020 (in Russ.).
This work is licensed under a Creative Commons «Attribution» 4.0 License.
Previous article
Next article
