Chronic prostatitis associated with herpesviruses
DOI: 10.32364/2587-6821-2024-8-4-6
Z.A. Kadyrov, Sh.V. Ramishvili, V.S. Stepanov, A.V. Ignatiev, Sh.G. Mashaneishvili
RUDN University, Moscow, Russian Federation
The most common microorganisms are herpesviruses, which are capable of infecting many organs and systems, including reproductive organs (due to their biological properties) causing in some cases the occurrence of infertility and life-threatening generalized infections. Among the many herpesviruses, there are 9 that are transmitted from humans: herpes simplex viruses types 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, herpes viruses types 6, 7, 8, as well as macacine herpesvirus 1.
In recent decades, there has been intensive research into their role in damage to the male reproductive system, including the prostate gland. The authors attempted to assess the possible association of herpesviruses with symptoms of chronic prostatitis and infertility, for which a search was conducted in the Pubmed database for the following search query: human papillomavirus, Epstein-Barr virus, cytomegalovirus, herpes virus 1, 2, 6, sexual transmission, sperm, prostatitis. Epidemiological studies concerning the possible association of herpesviruses with chronic prostatitis (CP) / chronic pelvic pain syndrome (CPPS) symptoms in young men have shown that viruses can enter the genital organs through sexual contact or a systemic route. However, some of them do not damage the male reproductive system organs, but rather affect sperm cells, leading to infertility. Despite the contradictory isolated studies, most of them indicated the role of herpesviruses in the damage to the male reproductive system, including the prostate gland, with spermatogenesis disorder and infertility occurrence. Thus, patients with CP/CPPS should be examined for the herpesvirus detection, since atypical, uncultivated, intracellular, as well as viral pathogens (along with typical pathogens) can play a role in the prostatitis progression.
Keywords: herpesviruses, Epstein-Barr virus, cytomegalovirus, herpes simplex virus type 1, herpes simplex virus type 2, human herpesvirus type 6, human papillomavirus, chronic prostatitis, infertility.
For citation: Kadyrov Z.A., Ramishvili Sh.V., Stepanov V.S., Ignatiev A.V., Mashaneishvili Sh.G. Chronic prostatitis associated with herpesviruses. Russian Medical Inquiry. 2024;8(4):–227 (in Russ.). DOI: 10.32364/2587-6821-2024-8-4-6.
ABOUT THE AUTHORS:
Zieratsho A. Kadyrov — Dr. Sc. (Med.), Professor, Head of the Department of Endoscopic Urology and Ultrasound Diagnostics, Medical Institute of the RUDN University; 6, Miklukho-Maklaya str., Moscow, 117198, Russian Federation; ORCID iD 0000-0002-1108-8138.
Shota V. Ramishvili — correspondence postgraduate student of the Department of Endoscopic Urology and Ultrasound Diagnostics, Medical Institute of the RUDN University; 6, Miklukho-Maklaya str., Moscow, 117198, Russian Federation; ORCID iD 0000-0002-7323-3126.
Vladimir S. Stepanov — Assistant Professor of the Department of Endoscopic Urology and Ultrasound Diagnostics, Medical Institute of the RUDN University; 6, Miklukho-Maklaya str., Moscow, 117198, Russian Federation; ORCID iD 0000-0003-0525-3026.
Alexey V. Ignatiev — postgraduate student of the Department of Endoscopic Urology and Ultrasound Diagnostics, Medical Institute of the RUDN University; 6, Miklukho-Maklaya str., Moscow, 117198, Russian Federation; ORCID iD 0000-0003-0525-3026.
Shakro G. Mashaneishvili — correspondence postgraduate student of the Department of Endoscopic Urology and Ultrasound Diagnostics, Medical Institute of the RUDN University; 6, Miklukho-Maklaya str., Moscow, 117198, Russian Federation; ORCID iD 0000-0002-0448-6859.
Contact information: Zieratsho A. Kadyrov, e-mail: zieratsho@yandex.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 18.02.2024.
Revised 15.03.2024.
Accepted 09.04.2024.
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