Role of matrix metalloproteinases in the pathogenesis of osteoarthritis

Role of matrix metalloproteinases in the pathogenesis of osteoarthritis

V.V. Tsurko, Yu.B. Chervyakova, N.V. Malysheva

Pirogov Russian National Research Medical University, Moscow

Osteoarthritis (OA) is a chronic, progressive disorder of the musculoskeletal system, characterized by inflammation and subsequent degenerative alterations in cartilage tissue, subchondral bone, synovial membrane, meniscus, and joint capsule. These changes lead to joint functional impairment and a consequent decline in quality of life.

Matrix metalloproteinases (MMPs) are pivotal in the pathogenesis of OA, functioning as active enzymes that degrade the primary components of the extracellular matrix in affected joints. The proteolytic activity of MMPs is initiated and regulated by tissue inhibitors of metalloproteinases (TIMPs). Research indicates elevated levels of various MMPs in both the tissues of inflamed joints and the synovial fluid of affected joints in OA. MMPs are produced by fibroblasts, macrophages, vascular smooth muscle cells, among others.

The aim of this review is to present the latest insights into the association between inflammation and osteoarthritis, with a particular focus on the significant role of MMPs in disease progression.

Keywords: osteoarthritis, inflammation, matrix metalloproteinases, aging.

For citation: Tsurko V.V., Chervyakova Yu.B., Malysheva N.V. Role of matrix metalloproteinases in the pathogenesis of osteoarthritis. RMJ. 2024;8:17–20.