Optimal urate-lowering therapy in patients with gout — modern version of the problem

V.V. Tsurko^1,2, M.A. Gromova¹

¹Pirogov Russian National Research Medical University, Moscow

²Russian Medical Academy of Continuous Professional Education, Moscow

Gout is the most common type of inflammatory arthritis caused by the deposition of monosodium urate crystals in the joints and surrounding tissues in the setting of hyperuricemia, characterized by painful acute pain leading to disability. The goal of long-term therapy is to reduce the level of serum uric acid (SUA), which helps to dissolve crystals and eliminate tophi, reduce the frequency of gout exacerbations and prevent progressive joint damage and comorbid pathology development. Despite the availability of national and international recommendations and the effective medications for gout treatment that have already been developed and applied in clinical practice, therapy results are commonly unsatisfactory. The reason for these drawbacks is commonly multifactorial, including the doc tor-patient interaction. Poor adherence to urate-lowering therapy (ULT) is a common and significant factor in adverse outcomes for patients. The article examines gaps in the gout treatment, discusses patient management, including treatment tactics for concomitant diseases, with the mandatory achievement of the SUA target level to improve adherence to oral therapy, which ultimately provides a controlled disease course and a favorable prognosis.

Keywords: gout, hyperuricemia, clinical recommendations, urate-lowering therapy, goal achievement, commitment.

For citation: Tsurko V.V., Gromova M.A. Optimal urate-lowering therapy in patients with gout — modern version of the problem. RMJ. 2021;7:50–54.