Post-vaccination hyperthermia in children: a current view of the old problem
DOI: 10.32364/2618-8430-2023-6-2-192-198
A.L. Zaplatnikov1, A.A. Girina2, I.V. Lepiseva3, V.I. Svintsitskaya1, M.V. Leshik1, A.V. Fursova1
1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
2Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation
3Children's Republican Hospital, Petrozavodsk, Russian Federation
According to the World Health Organization, “immunization is recognized as a core component of the human right to health.” However, the successes of vaccine prophylaxis could be nullified by the currently common vaccine hesitancy. The reasons behind immunization refusal encompass misconceptions related to a high rate of vaccination complications and a considerable overestimation of the role of vaccine adverse events in the development of various pathological conditions. In this context, particular concerns are caused by the potential occurrence of fever in children after an immunization and the risk of febrile seizures that may develop under such circumstances. The article is focused on the prevention and treatment of hyperthermia occurring after an immunization. However, based on the analysis of research findings a conclusion has been made that the administration of antipyretic analgesics (acetaminophen, ibuprofen) before vaccination does not prevent the onset of febrile seizures. At the same time, the use of mentioned drugs during the developed post-vaccination hyperthermia is justified and characterized by a high therapeutic efficacy. As emphasized, the early administration of antipyretic analgesics to control fever after vaccination could be recommended to children with febrile seizures in the medical history. The authors present the latest data of scientific literature demonstrating that the prophylactic antipyretic administration before an immunization may affect the vaccine-induced immunity and should not be recommended for a common use.
Keywords: antipyretics, acetaminophen, vaccine adverse events, vaccination, children, ibuprofen, immunization, paracetamol, post-vaccination hyperthermia, febrile seizures.
For citation: Zaplatnikov A.L., Girina A.A., Lepiseva I.V. et al. Post-vaccination hyperthermia in children: a current view of the old problem. Russian Journal of Woman and Child Health. 2023;6(2):192–198 (in Russ.). DOI: 10.32364/2618-8430-2023-6-2-192-198.
About the authors:
Andrey L. Zaplatnikov — Dr. Sc. (Med.), professor, Vice-Rector for Academic Affairs, Head of the Prof. V.V. Gavryushov Department of Neonatology, Professor of the Acad. G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0003-1303-8318.
Asiya A. Girina — C. Sc. (Med.), associate professor of the Department of Pharmacology, Pediatrics and Infectious Diseases, Khanty-Mansiysk State Medical Academy; 40, Mira str., Khanty-Mansiysk, 628011, Russian Federation; ORCID iD 0000-0002-5281-1564.
Inga V. Lepiseva — Chief Physician, Children's Republican Hospital; 58, Parkovaya str., Petrozavodsk, 185000, Russian Federation; ORCID iD 0000-0001-8989-6103.
Victoria I. Svintsitskaya — C. Sc. (Med.), associate professor of the Acad. G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0002-9272-2339.
Maria V. Leshik — assistant of the Acad. G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0002-9331-1419.
Anna D. Fursova — resident of the Prof. V.V. Gavryushov Department of Neonatology, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation.
Contact information: Andrey L. Zaplatnikov, e-mail: zaplatnikov@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 03.03.2023.
Revised 27.03.2023.
Accepted 17.04.2023.
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