Clinical symptom complexes in the diagnosis of renal kidney tumors in children
DOI: 10.32364/2618-8430-2023-6-3-14
E.A. Karavaeva1, T.E. Taranushenko2, M.V. Borisova 1
1Krasnoyarsk Regional Clinical Center for Maternal and Child Welfare, Krasnoyarsk, Russian Federation
2Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
Aim: to present data on kidney tumor clinical patterns and leading symptom sets at the examination stage in the tertiary care (specialized department in a hospital setting) based on modern diagnostic methods for the detection of kidney tumors.
Patients and Methods: this paper presents the results of a pilot study concerning the patterns of renal tumors (including nephroblastoma) in children and adolescents living in the Krasnoyarsk Territory. The data obtained are necessary for solving scientific and practical tasks to improve the provision of medical care in this pathology. The case histories of 57 children and adolescents with renal tumors who were hospitalized for examination and treatment in the Department of Oncology and Hematology (Krasnoyarsk Regional Clinical Center for Maternal and Child Welfare) from 2011 to 2021 were analyzed. All patients lived on the territory of the Krasnoyarsk Territory.
Results and Discussion: the study, conducted for the first time in the Krasnoyarsk Territory, presented the main symptom set of renal tumors in children, including clinical manifestations, as well as data of laboratory and instrumental research methods at the stage of primary tumor diagnosis. The most common specific clinical manifestation of the renal tumor was palpable volumetric mass of the abdominal cavity and abdominal volume increase, which was consistent with the literature data. Abdominal pain and anemia were most common among the non-specific symptoms. Ultrasound showed high efficiency for the primary tumor diagnosis, while computer and contrast-enhanced magnetic resonance imaging proved to be indispensable for the clinical tumor assessment (its spread and metastasis) for more rational treatment tactics.
Conclusions: information about clinical manifestations (given the specific and non-specific symptoms), concomitant pathology, data from instrumental and laboratory research methods at the stage of primary tumor diagnosis in children living in Eastern Siberia were presented for the first time.
Keywords: nephroblastoma, Wilms tumor, renal tumors, kidney tumors in children, specific and non-specific symptoms, SIOP studies, hematological and oncological diseases in children.
For citation: Karavaeva E.A., Taranushenko T.E., Borisova M.V. Clinical symptom complexes in the diagnosis of kidney tumors in children. Russian Journal of Woman and Child Health. 2023;6(3):304–309 (in Russ.). DOI: 10.32364/2618-8430-2023-6-3-14.
About the authors:
Elena A. Karavaeva — pediatric oncologist, hematologist, Department of Oncology and Hematology, Krasnoyarsk Regional Clinical Center for Maternal and Child Welfare; 2А, Akademika Kirenskogo str., Krasnoyarsk, 660074, Russian Federation; ORCID iD 0000-0002-8835-2806.
Tatyana E. Taranushenko — Dr. Sc. (Med.), Honored Doctor of the Russian Federation, Chief Pediatric Endocrinologist of the Ministry of Health of the Krasnoyarsk Territory; Professor, Head of the Department of Pediatrics of the Institute of Postgraduate Education, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; 1, Partizan Zheleznyak str., Krasnoyarsk, 660022, Russian Federation; Lead Consultant, Member of the Public Council of the Krasnoyarsk Regional Clinical Center for Maternal and Child Welfare; 2А, Akademika Kirenskogo str., Krasnoyarsk, 660074, Russian Federation; ORCID iD 0000-0003-2500-8001.
Marina V. Borisova — C. Sc. (Med.), Chief Consultant pediatric oncologist-hematologist of the Ministry of Health of the Krasnoyarsk Territory, Head of the Department of Oncology and Hematology, Krasnoyarsk Regional Clinical Center for Maternal and Child Welfare; 2А, Akademika Kirenskogo str., Krasnoyarsk, 660074, Russian Federation; Associate Professor of the Department of Children's Diseases, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; 1, Partizan Zheleznyak str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0003-4338-4940.
Contact information: Elena A. Karavaeva, e-mail: pasharina@yandex.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 25.04.2023.
Revised 23.05.2023.
Accepted 16.06.2023.
2. Graf N., Rübe C., Gessler M. Nierentumoren. In: Gadner H., Gaedicke G., Niemeyer C.H., Ritter J., hrsg. Pädiatrische Hämatologie und Onkologie. Springer-Verlag; 2006. DOI: 10.1007%2F3-540-29036-2.
3. Reinhard H., Semler O., Bürger D. et al. Results of the SIOP 93-01/GPOH trial and study for the treatment of patients with unilateral nonmetastatic Wilms Tumor. Klin Padiatr. 2004;216(3):132–140. DOI: 10.1055/s-2004-822625.
4. Качанов Д.Ю., Митрофанова А.М., Щербаков А.П. и др. Перилобарные остатки нефрогенной стромы гиперпластического типа левой почки: трудности дифференциальной диагностики с нефробластомой. Российский журнал детской гематологии и онкологии. 2016;3(1):67–69. DOI: 10.17650/2311-1267-2016-3-1-67-69. [Kachanov D.Yu., Mitrofanova A.M., Shcherbakov A.P. et al. Railing bar remnants of the hyperplastic left kidney nephrogenic stroma: difficulties of differential diagnosis with nephroblastoma. Russian Journal of Pediatric Hematology and Oncology. 2016;3(1):67–69 (in Russ.)]. DOI: 10.17650/2311-1267-2016-3-1-67-69.
5. SIOP Renal Tumour Study Group. Paediatric renal tumours: perspectives from the SIOP-RTSG. Nat Rev Urol. 2017;14(1):3–4. DOI: 10.1038/nrurol.2016.247.
6. Stein R., Graf N. Urologic Tumors in Childhood: Nephroblastoma and Wilms Tumor. In: Merseburger A., Burger M., eds. Urologic Oncology. Springer; 2019. DOI: 10.1007/978-3-319-42603-7_43-1.
7. Zekri W., Yacoub D.M., Ibrahim A., Madney Y. Relapsed Wilms' tumor in pediatric patients: challenges in low- to middle-income countries-a single-center experience. J Egypt Natl Canc Inst. 2020;32(1):21. DOI: 10.1186/s43046-020-00032-6.
8. Cook G., Caldwell K., Adhikar L., Patel S. Adult Wilms' Tumor: A Rare Case Report. Journal of Urological Surgery. 2018;5(4):205–207. DOI: 10.4274/jus.1668.
9. Oudmaijer C.A.J., van den Boogaard W.M.C., Komninos D.S.J. et al. Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity. Front Pediatr. 2022;10:828615. DOI: 10.3389/fped.2022.828615.
10. Welter N., Furtwängler R., Schneider G. et al. Tumorprädispositionssyndrome und Nephroblastom: Frühe Diagnose mit Bildgebung [Tumor predisposition syndromes and nephroblastoma: Early diagnosis with imaging]. Radiologie (Heidelb). 2022;62(12):1033–1042 (German). DOI: 10.1007/s00117-022-01056-w.
11. Yan Z., Meng Q., Yang J. et al. Identification of proteins associated with pediatric bilateral Wilms tumor. Oncol Lett. 2016;12(6):5075–5079. DOI: 10.3892/ol.2016.5306.
12. Chintagumpala M.M., Perlman E.J., Tornwall B. et al. Outcomes based on histopathologic response to preoperative chemotherapy in children with bilateral Wilms tumor: A prospective study (COG AREN0534). Cancer. 2022;128(13):2493–2503. DOI: 10.1002/cncr.34219.
13. Andre F., Arnedos M., Goubar A. et al. Ki67 — no evidence for its use in node-positive breast cancer. Nat Rev Clin Oncol. 2015;12(5):296–301. DOI: 10.1038/nrclinonc.2015.46.
14. Zhu X., Chen L., Huang B. et al. The prognostic and predictive potential of Ki-67 in triple-negative breast cancer. Sci Rep. 2020;10(1):225. DOI: 10.1038/s41598-019-57094-3.
This work is licensed under a Creative Commons «Attribution» 4.0 License.
Распечатать