Viral etiology of colorectal cancer
DOI: 10.32364/2587-6821-2021-5-8-538-544
Yu.Yu. Petukhova1,2, A.G. Petukhova1, E.V. Eliseeva1, V.I. Apanasevich1
1Pacific State Medical University, Vladivostok, Russian Federation
2Primorsky Regional Oncological Dispensary, Vladivostok, Russian Federation
Nowadays, colorectal cancer (CRC) ranks 3rd in prevalence among men with oncological diseases and 2nd in women. Adding that, there is a tendency to increase the incidence of CRC among young patients. The most important factor in the CRC prevention is screening, the clinical value of which is reflected in the ability to prevent cancer morbidity and mortality, as well as in reducing treatment costs by detecting precancerous pathologies and early stages of cancer. The review aims at systematizing the study results devoted to the viral etiology of CRC. Up-to-date data on the association of CRC with human papillomavirus, cytomegalovirus and Epstein-Barr virus is presented. Research data on the role of viruses in the CRC pathogenesis are insufficient and contradictory. The structure of the analyzed studies, the sample size, as well as the methods used to detect viruses, differ markedly. Therefore, they do not allow obtaining reliable results, which dictates the need for further problem study. Understanding the mechanisms by which viruses maintain and stimulate virulence is an important step towards developing treatment tactics in cancer associated with oncoviruses.
Keywords: colorectal cancer, human papillomavirus, cytomegalovirus, Epstein-Barr virus, colon polyps, adenomatous polyps, adenocarcinoma, oncoviruses.
For citation: Petukhova Yu.Yu., Petukhova A.G., Eliseeva E.V., Apanasevich V.I. Viral etiology of colorectal cancer. Russian Medical Inquiry. 2021;5(8):538–544 (in Russ.). DOI: 10.32364/2587-6821-2021-5-8-538-544.
About the authors:
Yulia Yu. Petukhova — postgraduate student of the Pacific State Medical University; 2, Ostryakova Avenue, Vladivostok, 690002, Russian Federation; Deputy Chief Officer for Clinical Care of the Primorsky Regional Oncological Dispensary; 59, Russkaya str., Vladivostok, 690105, Russian Federation; ORCID iD 0000-0002-0724-9736.
Antonina G. Petukhova — 6th year student of the Pacific State Medical University; 2, Ostryakova Avenue, Vladivostok, 690002, Russian Federation; ORCID iD 0000-0002-0387-098Х.
Ekaterina V. Yeliseeva — Dr. Sc. (Med.), Professor, Head of the Department of General and Clinical Pharmacology, Vice-Rector of the Pacific State Medical University; 2, Ostryakova Avenue, Vladivostok, 690002, Russian Federation; ORCID iD 0000-0001-6126-1253.
Vladimir I. Apanasevich — Dr. Sc. (Med.), Professor of the Institute of Surgery, Pacific State Medical University; 2, Ostryakova Avenue, Vladivostok, 690002, Russian Federation; ORCID iD 0000-0003-0808-5283.
Contact information: Yulia Yu. Petukhova, e-mail: juliapetukhovavl@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 27.04.2021.
Revised 17.05.2021.
Accepted 01.06.2021.
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