Clinical characteristics of cutaneous melanoma in patients of different age
DOI: 10.32364/2587-6821-2020-4-3-137-142
L.Ya. Rozenko, E.M. Frantsiyants, M.A. Gusareva, M.S. Zin’kovich, N.G. Kosheleva,
E.O. Vasil’eva, Yu.N. Krokhmal’, A.K. Donskaya, A.A. Solntseva, N.B. Fat’kina
National Medical Research Centre for Oncology, Rostov-on-Don, Russian Federation
Aim: to identify specific clinical characteristics of patients with cutaneous melanoma of different gender and age.
Patients and Methods: retrospective analysis of medical records of 53 patients with primary cutaneous melanoma was performed. The patients were divided into two age groups. Group 1 included 26 patients under 55 years, mean age was 41.9±8.9 years (26–54 years), 15 women and 11 men. Group 2 included 27 patients older than 55 years, mean age 66.2±7.1 years (55–82 years), 15 women and 12 men. Confirmed anamnestic data, the results of clinical and physical examination and standard instrumental tests, and verified intercurrent diseases were analyzed.
Results: male-to-female sex ratio was 1:1.3. Melanoma elsewhere on the extremities was more common in women <55 years than in women ≥55 years and men (73.3, 40.0, and 18.2%, respectively; р<0.05). Scalp melanoma was more common in men (regardless of age) than in women (34.8% vs. 6.7%; р<0.05). In men and women <55 years, nodular melanoma and melanoma in congenital nevi were found in 65.4% and 73.0%, respectively. In men and women ≥55 years, nodular melanoma and melanoma in congenital nevi were found in 25.9% and 33.3%, respectively (р<0.05), i.e., melanoma de novo was common in these patients. A history of melanoma was significantly longer in patients ≥55 years than in patients <55 years regardless of gender (17.9±4.2 months and 6.5±3.9 months, respectively). Comorbid conditions and other cancers were 2.6 times more common in patients ≥55 years than in patients
<55 years (р<0.05).
Conclusion: our analysis provides the hallmarks of the clinical course of cutaneous melanoma and contributes to its early diagnosis. In-depth study of the effect of intercurrent diseases in terms of the etiology and pathogenesis of cutaneous melanoma is useful.
Keywords: cutaneous melanoma, age of patients, gender of patients, medical history, tumor site, morphology.
For citation: Rozenko L.Ya., Frantsiyants E.M., Gusareva M.A. et al. Clinical characteristics of cutaneous melanoma in patients of different age. Russian Medical Inquiry. 2020;4(3):137–142. DOI: 10.32364/2587-6821-2020-4-3-137-142.
2. Kaprin A.D., Starinskiy V.V., Petrova G.V. The status of cancer care for the population of Russia in 2018. Moscow: MNIOI n.a. P.A. Gertsen; 2019 (in Russ.).
3. Prokhorov D.V., Gorlova N.A., Sherengovskaya Yu.V. et al. Comparative analysis of the incidence of melanoma and skin cancer in the Republic of Crimea and the Russian Federation. Tavricheskii mediko-biologicheskii vestnik. 2019;22(1):83–85 (in Russ.).
4. Anisimov V.V. Skin melanoma. Part I. (Electronic resourse). URL: http://www.onkologkozha.ru/melanoma_I06.htm (access date: 31.05.2020) (in Russ.).
5. Demidov L.V., Kharkevich G.Yu. Adjuvant treatment of patients with skin melanoma. Prakticheskaya onkologiya. 2001;4(8):42–48 (in Russ.).
6. Rubtsov V.R., Nepomnyashchaya E.M., Gusareva M.A. Aspects of diagnosis and treatment of skin melanoma. Izvestiya vysshikh uchebnykh zavedeniy. Severo-Kavkazskiy region. Estestvennye nauki. 2005;(1):69–72 (in Russ.).
7. Pozdnyakova V.V. Prevalence, pathogenesis, treatment and prevention of skin melanoma. Izvestiya vysshikh uchebnykh zavedeniy. Severo-Kavkazskiy region. Estestvennye nauki. 2006; S1:17–20 (in Russ.).
8. Lemekhov V.G. Epidemiology, risk factors, screening of skin melanoma. Prakticheskaya onkologiya. 2001;(8):3–11 (in Russ.).
9. Ruksha T.G., Kirichenko A.K., Sergeeva E.Yu. et al. Skin melanoma. Moscow: Litterra; 2016 (in Russ.).
10. Malishevskaya N.P., Sokolova A.V., Demidov L.V. The incidence of skin melanoma in the Russian Federation and federal districts. Meditsinskiy sovet. 2018;10:161–165 (in Russ.).
11. Sobin L.H., Gospodarowicz M.K., Wittekind C. The TNM classication of malignant tumours 8th edition, 8th edn: Wiley-Blackwell; 2009.
12. Anisimov V.V. Skin melanoma (epidemiology, etiology, pathogenesis, prevention) (Part 2). Saint Petersburg: Nauka; 1995 (in Russ.).
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