Hallmarks of medical treatment of pseudoexfoliative glaucoma 
Brezhnev A.Yu. 

Kursk State Medical University

Pseudoexfoliative glaucoma (PEG) is characterized by high level of intraocular pressure (IOP), significant diurnal IOP fluctuation, process asymmetry, advanced degree of visual function degradation at the stage of detection that determines poor prognosis. Last data on PEG genetic, morphological, immunological and clinical features allows to consider the disease as a specific form of glaucoma process, requiring, additionally to standard technologies, the development of new, specific approaches to early diagnosis, medical and surgical correction. Hallmarks of topical hypotensive PEG treatment are: necessity of more pronounced IOP reduction with minimal IOP fluctuation (start therapy with prostaglandin analogues or fixed-dose combinations), prevention of «dry eye» syndrome development (usage of preservative-free glaucoma medications). Additional evidence-based «non-hypothensive» properties are desirable in prescribed medications (influence on regional hemodynamics, normalization of some metabolites level in the trabecular meshwork and anterior chamber, neuroprotective mechanisms). The paper presents epidemiological aspects of PEG, results of clinical trials on PEF medical treatment.

Key words: pseudoexfoliative glaucoma, medical treatment, prostaglandin analogues, dry eye syndrome, preservative-free medications.

For citation: Brezhnev A.Yu. Hallmarks of medical treatment of pseudoexfoliative glaucoma// RMJ. Clinical ophthalmology. 2016. № 4. P. 220–223.