Asthenia correction in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation (case report)
DOI: 10.32364/2587-6821-2023-7-10-13
A.Yu. Polushin1, Ya.B. Skiba1, O.G. Smykova1, I.Yu. Nikolaev1, N.A. Eliseev1, D.N. Abukov1, A.Yu. Sokolov1,2
1I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
2I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences, St. Petersburg, Russian Federation
Asthenic syndrome is one of the most common conditions in the clinical practice of medical specialists having various therapeutic spheres. The genesis of asthenic disorder is diverse and can be represented by cerebrovascular pathology, metabolic disorders, hypoxia of various origin, as well as intoxication. Asthenic syndrome can be diagnosed in 70–75% of patients with oncological pathology at various treatment stages. The article presents a case study concerning the asthenic syndrome progression in a patient with acute lymphoblastic leukemia (ALL) and its successful correction by metabolic therapy course. Case study pattern consist in the occurrence of this syndrome in the setting of multiple factors (infectious, metabolic, associated with intracranial hemorrhage) in the early period after hematopoietic stem cell transplantation (HSCT). The article provides a pathogenetic justification for the therapy indication with antihypoxants (cytochrome C) in patients with oncological pathology aimed at the asthenic syndrome correction in this patient cohort. Cytochrome C is a heme-containing protein of natural molecular origin. It is a participant in the process of cellular respiration and a regulator of redox processes in tissues. Successful correction of asthenic syndrome in patients with oncological pathology is an important task, the solution of which is of undoubted practical value.
Keywords: asthenia, asthenic syndrome, cytochrome C, leukemia, transplantation, hematopoietic stem cell transplantation, antihypoxants, metabolic therapy.
For citation: Polushin A.Yu., Skiba Ya.B., Smykova O.G., Nikolaev I.Yu., Eliseev N.A., Abukov D.N., Sokolov A.Yu. Asthenia correction in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation (case report). Russian Medical Inquiry. 2023;7(10):693–699 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-13.
About the authors:
Alexey Yu. Polushin — C. Sc. (Med.), neurologist, Head of the Department of Chemotherapy and Bone Marrow Transplantation in Oncological and Autoimmune Diseases, Head of the Laboratory of Neuro-Oncology and Autoimmune Diseases of the R.M. Gorbacheva Research Institute of Children Oncology, Hematology and Transplantation, Associate Professor of the Department of Neurology, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy str., St. Petersburg, 197022, Russian Federation; ORCID iD 0000-0001-8699-2482.
Yaroslav B. Skiba — C. Sc. (Med.), neurologist, Researcher at the Laboratory of Neuro-Oncology and Autoimmune Diseases of the R.M. Gorbacheva Research Institute of Children Oncology, Head of the Laboratory of Clinical Pharmacology and Pain Management of the Department of Neuropharmacology of the A.V. Valdman Institute of Pharmacology, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy str., St. Petersburg, 197022, Russian Federation; ORCID iD 0000-0003-1955-1032.
Olesya G. Smykova — hematologist of the Clinic of the R.M. Gorbacheva Research Institute of Children Oncology, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy str., St. Petersburg, 197022, Russian Federation; ORCID iD 0009-0004-5604-0666.
Ilya Yu. Nikolaev — radiologist of the Clinic of the R.M. Gorbacheva Research Institute of Children Oncology, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy str., St. Petersburg, 197022, Russian Federation; ORCID iD 0000-0002-8589-4618.
Nikolay A. Yeliseev — functional medicine practitioner of Outpatient Clinic No. 31 with Consulting and Diagnostic Center, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy str., St. Petersburg, 197022, Russian Federation; ORCID iD 0009-0002-3007-3430.
Dahir N. Abukov — neurosurgeon of the Neurosurgical Department 1, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy str., St. Petersburg, 197022, Russian Federation; ORCID iD 0000-0001-8217-734.
Alexey Yu. Sokolov — Dr. Sc. (Med.), Associate Professor, Head of the Department of Neuropharmacology, A.V. Valdman Institute of Pharmacology; Professor of the Department of Pharmacology, I.P. Pavlov First St. Petersburg State Medical University; 6–8, Lev Tolstoy str., St. Petersburg, 197022, Russian Federation; Senior Researcher at the Laboratory of Cortico-visceral Physiology, I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences; 6, Makarov emb., St. Petersburg, 199034, Russian Federation; ORCID iD 0000-0002-6141-486X.
Contact information: Yaroslav V. Skiba, e-mail: yaver-99@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 17.07.2023.
Revised 07.08.2023.
Accepted 28.08.2023.
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