Multiple meningiomas (case report)
DOI: 10.32364/2587-6821-2024-8-10-6
N.L. Starikova1, O.V. Bystrova1, A.A. Kornilovich2
1Academician E.A. Vagner Perm State Medical University, Perm, Russian Federation
2Perm Territorial Clinical VA Hospital, Perm, Russian Federation
Meningiomas, extracerebral tumors of the dura mater, are the most common tumors of the nervous system (i.e., 15% of all the intracranial neoplasms and 30–35% of central nervous system tumors). Multiple meningiomas are 1–10% of all the meningioma cases. This disease is more common in elderly patients (average age of the first meningioma detection is about 55 years), and it represents a major issue for diagnosis and management selection. Both sporadic meningiomatosis cases and a family history of autosomal dominant meningiomatosis are reported. A number of meningiomas per a patient can vary from 2–5 to ≥50; they can be located supratentorially, infratentorially and throughout the spinal canal. Multiple meningiomas have a negative effect on the disease prognosis. According to available data, each newly detected lesion leads to a progressive decrease in a survival rate. The paper presents a brief literature review on diagnosis and treatment of multiple meningiomas, as well as clinical observation of a young patient with sequentially detected multiple meningiomas (12 lesions) localized intracranially and throughout the spinal canal and mutation in the SMARCE1 gene.
Keywords: multiple meningiomas, meningiomatosis, sporadic meningiomatosis, diagnosis, disease management.
For citation: Starikova N.L., Bystrova O.V., Kornilovich A.A. Multiple meningiomas (case report). Russian Medical Inquiry. 2024;8(10):582–586 (in Russ.). DOI: 10.32364/2587-6821-2024-8-10-6
About the authors:
Nataliya L. Starikova — Dr. Sc. (Med.), Professor of the Department of Neurology and Medical Genetics, Academician E.A. Vagner Perm State Medical University; 26, Petropavlovskaya str., Perm, 614990, Russian Federation; ORCID iD 0000-0002-8350-7004
Olga V. Bystrova — C. Sc. (Med.), Assistant Professor of the Department of Physical Rehabilitation Medicine with Sociomedical Expertising Course, Academician E.A. Vagner Perm State Medical University; 26, Petropavlovskaya str., Perm, 614990, Russian Federation; ORCID iD 0009-0008-0358-102X
Anna A. Kornilovich — neurologist, Perm Territorial Clinical VA Hospital; 6, Podlesnaya str., Perm, 614097, Russian Federation.
Contact information: Nataliya L. Starikova, e-mail: nlsta@mail.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 12.08.2024.
Revised 04.09.2024.
Accepted 27.09.2024.
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