Correction of post-stroke cognitive and motor disorders
DOI: 10.32364/2587-6821-2020-4-9-584-589
A.V. Chugunov1, L.I. Pyshkina1, Z.Kh. Osmayeva2
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2Chechen State University, Grozny, Russian Federation
Ischemic stroke (IS) is one of the main causes of fatal income and disability in most developed countries. Disability due to IS is primarily caused by motor (paresis, ataxia), cognitive and emotional disorders. Post-stroke depression and dementia are associated not only with low compliance to rehabilitation measures and their low efficacy, but also with an increased risk of repeated episodes of acute brain and coronary ischemia, and mortality from cardiovascular diseases. Correction of post-stroke disorders is a complex process; its effectiveness is ensured by timely detection of disorders, early treatment onset, and combined use of medications and non-medications. The article discusses methods to the treatment of patients who have experienced IS, receiving choline alfoscerate. The results of drug administration in both acute and long-term IS were analyzed. Improvement of motor, cognitive and emotional functions was noted. Good tolerability of the drug and the possibility of i ts simultaneous use with other drugs were emphasized.
Keywords: ischemic stroke, post-stroke depression, post-stroke cognitive impairment, hemiparesis, neurometabolic drugs, choline alfoscerate, treatment, rehabilitation.
For citation: Chugunov A.V., Pyshkina L.I., Osmayeva Z.Kh. Correction of post-stroke cognitive and motor disorders. Russian Medical Inquiry. 2020;4(9):584–589. DOI: 10.32364/2587-6821-2020-4-9-584-589.
Acknowledgment
Editorial Board is grateful to “Sotex” Pharm Firm” for the assistance in technical edition of this publication.
About the authors:
Alexander V. Chugunov — Cand. of Sci. (Med.), Professor of the Department of Neurology, Neurosurgery and Medical Genetics, Faculty of General Medicine, Pirogov Russian National Research Medical University: 1, Ostrovityanova str., Moscow, 117997, Russian Federation; ORCID iD 0000-0003-4506-8095.
Ludmila I. Pyshkina — Dr. of Sci. (Med.), Professor of the Department of Neurology, Neurosurgery and Medical Genetics, Faculty of General Medicine, Pirogov Russian National Research Medical University: 1, Ostrovityanova str., Moscow, 117997, Russian Federation; ORCID iD 0000-0003-0268-0735.
Zareta Kh. Osmayeva — Assistant Professor of the Department of Neurology and Psychiatry of the Medical Institute, Chechen State University: 32, A. Sheripova str., Grozny, 364093, Russian Federation; ORCID iD 0000-0002-0889-4227.
Contact information: Alexander V. Chugunov, e-mail: warmtree@mail.ru. Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 05.10.2020, revised 19.10.2020, accepted 02.11.2020.
2. Backholer K., Peters S., Bots S. et al. Sex differences in the relationship between socioeconomic status and cardiovascular disease: a systematic review and meta-analysis. J Epidemiol Community Health. 2017;71(6):550–557. DOI: 10.1136/jech-2016-207890.
3. Lopez A., Adair T. Is the long-term decline in cardiovascular-disease mortality in high-income countries over? Evidence from national vital statistics. Int J Epidemiol. 2019;48:1815–1823. DOI: 10.1093/ije/dyz143.
4. Jokinen H., Melkas S., Ylikoski R. et al. Post-stroke cognitive impairment is common even after successful clinical recovery. Eur J Neurol. 2015;22:1288–1294. DOI: 10.1111/ene.12743.
5. Sachdev P., Lipnicki D., Crawford J. et al. Progression of cognitive impairment in stroke/TIA patients over 3 years. J Neurol Neurosurg Psychiatry. 2014;85:1324–1330. DOI: 10.1136/jnnp-2013-306776.
6. Mijajlovic M., Pavlovic A., Brainin M. et al. Post-stroke dementia: a comprehensive review. BMC Med. 2017;15(1):11. DOI: 10.1186/s12916-017-0779-7.
7. Levine D., Galecki A., Langa K. et al. Trajectory of cognitive decline after incident stroke. JAMA. 2015;1:41–51. DOI: 10.1001/jama.2015.6968.
8. Cumming T., Churilov L., Linden T., Bernhardt J. Montreal Cognitive Assessment and MiniMental State Examination are both valid cognitive tools in stroke. Acta Neurol Scand. 2013;128:122–129. DOI: 10.1111/ane.12084.
9. Terroni L., Matildas F., Conforto A. et al. Association among depression, cognitive impairment and executive dysfunction after stroke. Dement Neuropsychol. 2012;6(3):152–157. DOI: 10.1590/S1980-57642012DN06030007.
10. Eriksson M., Norrving B., Asplund K. Poststroke suicide attempts and completed suicides. Neurology. 2015;84:1732–1738. DOI: 10.1212/WNL.0000000000001514.
11. Pompili M., Venturini P., Lamis D. et al. Suicide in stroke survivors: epidemiology and prevention. Drugs Aging. 2015;32(1):21–29. DOI: 10.1007/s40266-014-0233-x.
12. Mikami K., Sudo T., Orihashi Y. et al. Effective tools to predict depression in acute and subacute phase of ischemic stroke. J Neuropsychiatry Clin Neurosci. 2020 Oct 22. Online ahead of print. DOI: 10.1176/appi.neuropsych.20040076.
13. Demnitz N., Anatürk M., Allan C. et al. Association of trajectories of depressive symptoms with vascular risk, cognitive function and adverse brain outcomes: The Whitehall II MRI sub-study. J Psychiatr Res. 2020;131:85–93. DOI: 10.1016/j.jpsychires.2020.09.005.
14. De Man-van Ginkel J.M., Hafsteinsdottir T.B., Lindeman L. et al. In-hospital risk prediction for post-stroke depression: development and validation of the Post-stroke Depression Prediction Scale. Stroke. 2013;44(9):2441–2445. DOI: 10.1161/STROKEAHA.111.000304.
15. Jiang X., Lin Y., Li Y. Correlative study on risk factors of depression among acute stroke patients. Eur Rev Med Pharmacol Sci. 2014;18(9):1315–1323. PMID: 24867509.
16. Filipska K., Wiśniewski A., Biercewicz M., Ślusarz R. Are depression and dementia a common problem for stroke older adults? a review of chosen epidemiological studies. Psychiatr Q. 2020;91(3):807–817. DOI: 10.1007/s11126-020-09734-5.
17. Hackett M.L., Pickles K. Frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies. Int J Stroke. 2014;9(8):1017–1025. DOI: 10.1111/ijs.12357.
18. Sun N., Li Q.J., Lev D.M. et al. A survey on 465 patients with post-stroke depression in China. Arch Psychiatr Nurs. 2014;28(6):368–371. DOI: 10.1016/j.apnu.2014.08.007.
19. Kosgallana A., Cordato D., Chan D., Yong J. Use of cognitive screening tools to detect cognitive impairment after an ischaemic stroke: a systematic review. SN Comprehensive Clinical Medicine. 2019;1:255–262. DOI: 10.1007/s42399-018-0035-2.
20. Gusev E.I., Bogolepova A.N. Cognitive disorders in cerebrovascular diseases. М.: Medpress-inform; 2012 (in Russ.).
21. Kamchatnov P.R., Abusueva B.A., Evselman M.A. et al. The effectiveness of cereton in acute ischemic stroke (study the SUN). S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(3):10–14 (in Russ.).
22. Batysheva T.N., Kamchatnov P.R., Boyko A.N. et al. The use of cereton in patients with mild cognitive disorders of vascular origin. Difficult patient. 2009;4–5:42–47 (in Russ.).
23. Levin O.S., Batukaeva L.A., Anikina M.A., Yunishchenko N.A. Efficacy and safety of choline alfoscerate (ceretone) in patients with Parkinson’s disease with cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2009;109(11):42–46 (in Russ.).
24. Barbagallo S.G., Giordano M. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial. Ann N Y Acad Sci. 1994;717:253–269.
25. Parnetti L., Amenta F., Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mech Ageing Dev. 2001;122(16):2041–2055. DOI: 10.1016/s0047-6374 (01) 00312-8.
26. Boyko A.N., Batysheva T.T., Bagir L.V. et al. Experience of outpatient use of the drug Cerepro in ischemic stroke in the early recovery period. S.S. Korsakov Journal of Neurology and Psychiatry. 2007;107(10):34–40 (in Russ.).
27. Buylova T.V., Glotova M.E., Halak M.E., Vashkevich V.V. Experience of using Tsereton in the rehabilitation of patients with hemorrhagic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2009;109(2);5:58–62 (in Russ.).
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