Time-proved pharmacotherapy: from mechanisms to clinical efficacy

M.L. Maximov¹, A.I. Malykhina², A.A. Shikaleva¹

¹Kazan State Medical University, the branch of the Russian Medical Academy of Continuous Professional Education, Kazan

²Center of Endosurgery and Lithotripsy (CELT) JSC, Moscow

This review article, based on the significant number of sources, describes the full range of pharmacological effects, the mechanism and aspects of the clinical use of the original national Dimephosphon^® (INN: dimethyloxobuthylphosphonilmethylate). Vasoactive and antihypoxic, neuroprotective and cerebroprotective, as well as antioxidant effects of this drug are considered. The article also notes the ability of this non-anticholinesterase organophosphorus compound to normalize cerebrovascular reactivity, reduce vascular tone, improve arterial elasticity, normalize regional blood flow and oxygen-dependent energy metabolism in the structures of the central nervous system. Adding that, this drug can optimize intracellular metabolism of the brain, prevent the reaction of lipid peroxidation and implement the antiacidotic effect by virtue of the intensification of the renal and pulmonary regulation mechanisms of the acid-base state body condition (as one of the most important and strictly stabilized parameters of homeostasis). Dimephosphon^® increases organ blood flow and tissue metabolism, and also leads to a decrease in the content of lactic and pyruvic acids in brain tissues. At present, there is a large clinical use of dimethyloxobuthylphosphonilmethylate in acute disorders of cerebral blood flow, postoperative and posttraumatic cerebral disorders, Meniere’s disease and autonomic dysfunction, as well as in cerebrospinal injury.

Keywords: dimephosphone, neuroprotector, cerebroprotector, antioxidant, antihypoxant, vasoprotector, blood flow, vascular tone, metabolism, acid-base condition.

For citation: Maximov M.L., Malykhina A.I., Shikaleva A.A. Time-proved pharmacotherapy: from mechanisms to clinical efficacy. RMJ. 2020;9:71–76.