Postoperative pain: prevention or treatment of consequences?
M.A. Strakhov^1,2, N.V. Zagorodniy^3,4, K.A. Yeghiazaryan¹, M.N. Pluzhnikova², N.V. Ovcharenko¹, T.G. Gaev<sup>2

1</sup>Pirogov Russian National Research Medical University, Moscow
²Federal Research and Clinical Center of the FMBA of Russia, Moscow
³Peoples’ Friendship University of Russia, Moscow
⁴National Medical Research Center of Traumatology and Orthopedics named after N.N. Priorov, Moscow

Postoperative pain remains an important problem for both surgeons and their patients. Optimization of postoperative analgesia is an important issue in terms of achieving clinical goals as soon as possible and minimizing complications and side effects of medication support. At present, the concept of multimodal analgesia is relevant, based on the combination of several drugs that differ in terms of their application points, but have an unidirectional effect on the mechanisms of pain realization and reduction of local hormonal response to the injury. This approach allows to achieve maximum analgesic effect at lower doses of specific drugs. At the same time, the dose-dependent frequency and severity of side effects of drugs decrease.
Medicines that implement the mechanisms of influence on both the peripheral and the central link of the pain pattern are now drugs of choice. The main component in the schemes of multimodal anesthesia are non-steroidal anti-inflammatory drugs. As an example, we can cite Ketonal^® (SJSC “Sandoz”), which in combination with other analgesic drugs, as well as in monotherapy, is able to quickly relieve severe pain syndrome and minimal side effects, which makes it an important component of various schemes of postoperative management.

Keywords: postoperative pain, chronization of pain, psychophysiology of pain, ketoprofen, Ketonal.
For citation: Strakhov M.A., Zagorodniy N.V., Yeghiazaryan K.A. et al. Postoperative pain: prevention or treatment of consequences? RMJ. 2019;2:3–7.