Interrelation of cardiac-vascular complications and non-alcoholic fatty liver disease
Akhmedov V.A.

Omsk State Medical University

The review analyses the pathogenetic mechanisms of cardiovascular diseases formation in patients with non-alcoholic fatty liver disease. The article considers the role of insulin resistance, pro-inflammatory cytokines, adipocytokines, genetic factors in the formation of atherosclerosis, diastolic left ventricular dysfunction and chronic heart failure. It is noted that ectopic accumulation of adipose tissue can be a key pathogenetic element in the formation of cardiovascular diseases, and therefore patients with NAFLD have a high risk of their development. It is shown that individuals with NAFLD and higher C protein levels have the highest risk of cardiovascular disease. It is demonstrated, that the degree of histological changes in the liver in patients with NAFLD correlates with atherosclerotic changes in the carotid arteries. The increase of transaminases in the biochemical blood test of patients with NAFLD is an independent risk factor for the formation of heart failure. It is noted that the echocardiographic signs of sclerotic changes in the aortic valve have a clear connection with NAFLD. It is shown that PNPLA3 GG genotype is associated with the severity of atherosclerotic changes in the carotid arteries in young patients with NAFLD.

Key words: non-alcoholic fatty liver disease, insulin resistance, risk, cardiovascular diseases, atherosclerosis.
For citation: Akhmedov V.A. Interrelation of cardiac-vascular complications and non-alcoholic fatty liver disease // RMJ. 2018. № 1(II). P. 86–88.