Possibilities of antihypertensive therapy in inadequate blood pressure control 
Zagidullin N.Sh., Sukhareva N.N.

Bashkir State Medical University, Ufa

The importance of diagnostics and treatment of arterial hypertension is only increasing with the time. Despite the existing number of antihypertensive medicines the adequate blood pressure control is not achieved because of the variety of reasons: frequency of administration, side effects, inadequate dosages, etc. In this review an attempt was made to create an algorithm for antihypertensive therapy based on valsartan in patients who do not control blood pressure at different degrees of hypertension, taking into account risks and target organ damages. The algorithm is also based on the clinical studies conducted in Russian population such as VICTORY study with valsartan and its combination with hydrochlorothiazide and the Russian observational study with combination valsartan and amlodipine. It has been shown that the titration of valsartan from 80 to 320 mg / day and its combination with hydrochlorothiazide contributes to the successful control of blood pressure in 91,0% of patients, leads to a good and very good therapeutic effect in 96,9 % of patients and has a high subjective assessment of the treatment. A combination of valsartan with amlodipine is effective at severe stages of hypertension and in patients with high cardiovascular risk. In particular, initial blood pressure 167.5±16,2/100.1±9.2 mm Hg can be decreased to target level in 80% of patients. Thus, the algorithm for the treatment of arterial hypertension was developed using valsartan and its combination with hydrochlorothiazide or amlodipine as the basic antihypertensive medicines to achieve blood pressure control in 80–91% of patients at different degrees of arterial hypertension.

Key words: arterial hypertension, inadequate control, blood pressure, combined therapy, algorithm for hypertension treatment.
For citation: Zagidullin N.Sh., Sukhareva N.N. Possibilities of antihypertensive therapy in inadequate blood pressure control // RMJ. 2017. № 11. P. 780–785.