Sartans and the problem of comorbidity
Kirichenko A.A.

Russian Medical Academy of Сontinuous Professional Education, Moscow

Comorbidity is the presence of two and/or more pathogenetically interrelated diseases in one patient. It occurs frequently, especially in elderly and old patients. Comorbidity increases the severity of the condition, worsens the prognosis and complicates the treatment. In the choice of antihypertensive drug, it is important not only to reach the target value of arterial pressure, but also to effect the mechanisms of development and the symptoms of concomitant diseases. Angiotensin II receptor blockers are involved in modulating the effect of angiotensin on cell growth, proliferation, inflammatory responses and oxidative stress. The studies of angiotensin receptor blockers have shown their multiple effects and the possibility of additional positive effects in chronic heart failure, myocardial hypertrophy of the left ventricle of the heart, heart rhythm disorders (atrial fibrillation), metabolic syndrome, diabetes mellitus, kidney disease, obstructive bronchial diseases, oncological diseases. Further study of the problem of comorbidity will allow to specify the prescription of medicines to patients with various cardiovascular diseases and concomitant pathology with common pathogenetic mechanisms and to reduce the number of the drugs used in therapy.

Key words: angiotensin II, angiotensin receptor blockers, comorbidity, cardiovascular diseases, hypertension, chronic heart failure, diabetes mellitus.
For citation: Kirichenko A.A. Sartans and the problem of comorbidity // RMJ. 2018. № 1(II). P. 110–114.