COVID-19-associated myocarditis: clinical pattern and medical treatment
DOI: 10.32364/2587-6821-2022-6-1-26-32
V.A. Sergeeva, T.E. Lipatova
V.I. Razumovskiy Saratov State Medical University, Saratov, Russian Federation
Myocarditis associated with the novel coronavirus infection (COVID-19) is a challenging diagnosis. Clinical presentations of this disease are either non-specific or occult. Meanwhile, long-term outcomes are unknown. Diagnostic approaches are challenging and virtually impossible to be applied in the COVID-19 hospitals. In addition, therapy for the COVID-19 infection is potentially harmful to the myocardium.
This review article summarizes currently available published data on the clinical aspects and medical treatment for inflammatory myocardial damage in the COVID-19 infection. More than 300 publications were analyzed. This paper addresses the most relevant information.
International published data provide strong evidence of the potential development of myocarditis secondary to the COVID-19 infection. Histological verification of myocardial damage is associated with significant differences since endomyocardial biopsy is not always possible in the setting of severe infection course. As a result, statistical data do not fully represent the prevalence of COVID-19-associated myocarditis. Pharmacotherapeutic strategies are generally empirical due to the understudied pathogenesis of inflammatory myocardial damage. Further studies are needed, given a controversial prognosis of COVID-19-associated myocarditis.
Keywords: COVID-19, SARS-CoV-2, myocarditis, myocardial damage, cardiovascular system, clinical presentations, treatment, drug effects.
For citation: Sergeeva V.A., Lipatova T.E. COVID-19-associated myocarditis: clinical pattern and medical treatment. Russian Medical Inquiry. 2022;6(1):26–32 (in Russ.). DOI: 10.32364/2587-6821-2022-6-1-26-32.
About the authors:
Victoria A. Sergeeva — C. Sc. (Med.), associate professor of the Department of Therapy with the Courses of Cardiology, Functional Diagnostics, and Geriatrics, V.I. Razumovskiy Saratov State Medical University; 112, Bolshaya Kazach’ya str., Saratov, 410012, Russian Federation; ORCID iD 0000-0003-3517-8231.
Tatjana. E. Lipatova — D. Sc. (Med.), Head of Department of Therapy with the Courses of Cardiology, Functional Diagnostics, and Geriatrics, V.I. Razumovskiy Saratov State Medical University; 112, Bolshaya Kazach’ya str., Saratov, 410012, Russian Federation; ORCID iD 0000-0002-7401-9930.
Contact information: Victoria A. Sergeeva, e-mail: viktoriasergeeva@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 17.11.2021.
Revised 10.12.2021.
Accepted 11.01.2022.
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