Interleukin 15 as a biological marker of cardiovascular diseases

A.M. Alieva¹, E.V. Reznik^{1, 2}, N.V. Teplova¹, L.R. Sarakaeva³, R.K. Valiev⁴, M.N. Sariyev⁴, M.Ya. Shavaeva⁵, A.M. Rakhaev⁵, D.A. Elmurzaeva⁵, I.G. Nikitin¹ 

¹Pirogov Russian National Research Medical University, Moscow

²City Clinical Hospital No. 31, Moscow

³V.A. Almazov National Medical Research Center, St. Petersburg

⁴A.S. Loginov Moscow Clinical Research Center, Moscow

⁵Kh.M. Berbekov Kabardian-Balkar State University, Nalchik 

Cardiovascular diseases are an important public health issue and one of the leading causes of mortality, decline or complete loss of work ability, and disability. According to the World Health Organization, more than 17 million people die from the complications of cardiovascular diseases every year, representing approx. 32% of all global deaths. Cardiovascular diseases represent a major socioeconomic burden in terms of healthcare resource use associated with the provision of medical care to patients and the mortality rate among the working-age population. Currently, an increasing number of novel biological markers have been identified to serve as a laboratory diagnostic tool and to predict the clinical course of cardiovascular disease, but only brain natriuretic peptide, its precursors, and cardiac troponins are most used in clinical practice. The article presents the results of a literature review of the promising biological marker interleukin 15 (IL-15) and its role in cardiovascular diseases. There is a growing body of evidence demonstrating the value of IL-15 as a novel biomarker for diagnosis and prognosis in patients with cardiac diseases. IL-15 may play an important role due to its cardioprotective effects. The final proof of the diagnostic, predictive and potential therapeutic implications of this marker would be received in the future large-scale prospective studies.

Keywords: cardiovascular diseases, biological marker, interleukin 15, atherosclerosis, ischemic heart disease, myocardial infarction, myocarditis.

For citation: Alieva A.M., Reznik E.V., Teplova N.V. et al. Interleukin 15 as a biological marker of cardiovascular diseases. RMJ. 2022;9:17–21.