Hypertension in postmenopausal women
Kotovskaya Yu.V.¹, Orlov A.V.<sup>2 

1</sup> People’s Friendship University of Russia, Moscow
² National Research Nuclear University (Moscow Engineering Physics Institute)

Hypertension is one of the most common cardiovascular diseases. Its prevalence in women is 54.45% and is slightly inferior to that of in men. In the over-55s, the prevalence of hypertension increases to 74.5% and is superior to that of in men (72.3%). 55-64 years are postmenopausal age (after the last menstrual period) which marks the permanent loss of ovarian functions and leads to estrogen deficiency. Estrogen deficiency which is of crucial importance for hypertension directly results in reduced production of potent vasodilators and antiplatelet factors (i.e., nitric oxide and prostacyclin), activation of local (tissue) renin-angiotensin and sympathetic systems, sodium retention, and insulin resistance. Neurohumoral changes due to menopause result in salt-sensitive hypertension. Current guidelines for hypertension include major principles of its therapy in postmenopausal women. Diuretics (single or in combination with other drugs, in particular, renin-angiotensin-aldosterone blockers) are a rational treatment strategy in these patients.

Key words: hypertension, postmenopausal period, hypertension in women, estrogen deficiency, diuretics, torasemide, Diuver.

For citation: Kotovskaya Yu.V., Orlov A.V. Hypertension in postmenopausal women // RMJ. 2016. № 19. P. 1312–1316.