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Cetylpyridinium chloride as a part of a combined medication for adults and children during the COVID-19 pandemic: established and perspective use

Abstract

DOI: 10.32364/2587-6821-2021-5-11-728-736

E.V. Melekhina1, A.D. Muzyka1, Zh.B. Ponezheva1, A.V. Gorelov1,2

1Central Research Institute of Epidemiology of the Russian Federal Service for Supervision
of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation

2A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow,


Russian FederationDespite the measures taken, SARS-CoV-2 continues to spread. However, an increase in acute respiratory infections (ARIs) in autumn 2021 is accounted for by the circulation of seasonal respiratory viruses, i.e., rhinovirus, respiratory syncytial virus, adenovirus, etc. The development of novel agents and study of the antiviral activity of well-established agents that inhibit the binding of SARS-CoV-2 and other respiratory viruses with nasopharyngeal and oropharyngeal receptors significantly reduces viral load. Cetylpyridinium chloride is an antiseptic without searing or damaging oropharyngeal epithelium that provides local effects without systemic immunomodulatory action. This agent is approved in Russian Federation for topical use in children over three years and adults as a part of a combined medication for infectious inflammatory throat diseases. This paper reviews current published data illustrating the antiviral activity of cetylpyridinium and its potential application as an antiseptic for preventive and therapeutic use in the COVID-19 pandemic.

Keywords: cetylpyridinium chloride, SARS-CoV-2, antiseptic, coronavirus infection, COVID-19, direct antiviral effect.

For citation: Melekhina E.V., Muzyka A.D., Ponezheva Zh.B., Gorelov A.V. Cetylpyridinium chloride as a part of a combined medication for adults and children during the COVID-19 pandemic: established and perspective use. Russian Medical Inquiry. 2021;5(11):728–736
(in Russ.). DOI: 10.32364/2587-6821-2021-5-11--736.

About the authors:

Elena V. Melekhina — Dr. Sc. (Med.), associate professor, leading researcher of the Clinical Division of Infectious Disorders, Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; 3A, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0000-0002-9238-9302.

Anna D. Muzyka — C. Sc. (Med.), senior researcher of the Clinical Division of Infectious Disorders, Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; 3A, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0000-0002-2260-2533.

Zhanna B. Ponezheva — Dr. Sc. (Med.), chief researcher, Head of the Clinical Division of Infectious Disorders, Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; 3A, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD

Aleksandr V. Gorelov — Dr. Sc. (Med.), Professor, Corresponding Member of the RAS, Deputy Director for Scientific Work, Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; 3A, Novogireevskaya str., Moscow, 111123, Russian Federation; Head of the Department of Infectious Diseases and Epidemiology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry; 20/1, Delegatskaya str., Moscow, 127473, Russian Federation; ORCID iD 0000-0001-9257-0171.

Contact information: Elena V. Melekhina, e-mail: e.melekhina@mail.ru.

Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.

There is no conflict of interests.

Received 18.09.2021.

Revised 12.10.2021.

Accepted 08.11.2021.

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