Vulvar intraepithelial neoplasia: a clinical protocol
DOI: 10.32364/2618-8430-2026-9-2-9
Vulvar intraepithelial neoplasia: a clinical protocol
Yu.E. Dobrokhotova, Zh.A. Mandrykina
Pirogov Russian National Research Medical University, Moscow, Russian Federation
In recent decades, non-inflammatory disorders of the vulva and perineum have been encountered with increasing frequency, which is attributable to the high population prevalence of human papillomavirus infection, as well as to the rising incidence of non-inflammatory dermatoses — a substantial contributing factor in the development of vulvar cancer. Whereas the issue of non-inflammatory vulvar and perineal disorders previously concerned primarily women in the pre- and postmenopausal periods, at present, regrettably, these conditions are increasingly being diagnosed in patients of reproductive age. In this context, Russian scientists and researchers, drawing on international experience, are developing new strategies and seeking additional opportunities for timely diagnosis, treatment, and prevention of these conditions, with the aim not only of prolonging women's lives but also of maximally improving their quality of life.
Until 2025, obstetrician-gynecologists had no clinical guidelines at their disposal for the patient management with dysplasia of the external genitalia. In the present article, we provide a detailed analysis of the key provisions in the new clinical guidelines "Vulvar intraepithelial neoplasia", developed by the Russian Society of Obstetricians and Gynecologists and approved in 2025, and examine the nuances of the classification, diagnosis, treatment, and prevention of this group of diseases.
Keywords: vulvar intraepithelial neoplasia, vulvar LSIL, vulvar HSIL, differentiated vulvar intraepithelial neoplasia, dVIN, HPV infection, HPV-associated vulvar neoplasia, vulvar dysplasia, vulvar cancer, vulvoscopy, histology, vulvar biopsy, lichen sclerosus, high-risk oncogenic HPV.
For citation: Dobrokhotova Yu.E., Mandrykina Zh.A. Vulvar intraepithelial neoplasia: a clinical protocol. Russian Journal of Woman and Child Health. 2026;9(2):152–157 (in Russ.). DOI: 10.32364/2618-8430-2026-9-2-9
About the authors:
Yulia E. Dobrokhotova — Dr. Sc. (Med.), Professor, Head of the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University; 1, build. 6, Ostrovityanova str., Moscow, 117513, Russian Federation; ORCID iD 0000-0002-7830-2290
Zhanna A. Mandrykina — C. Sc. (Med.), Associate Professor at the Department of Obstetrics and Gynecology, Institute of Surgery, Pirogov Russian National Research Medical University; 1, build. 6, Ostrovityanova str., Moscow, 117513, Russian Federation; ORCID iD 0000-0001-5702-3412
Contact information: Zhanna A. Mandrykina, e-mail: Shanna-man@mail.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 15.07.2025.
Revised 07.08.2025.
Accepted 01.09.2025.
2. Singh N., Gilks C.B. Vulval squamous cell carcinoma and its precursors. Histopathology. 2020;76(1):128–138. DOI: 10.1111/his.13989
3. Lebreton M., Carton I., Brousse S. et al. Vulvar intraepithelial neoplasia: Classification, epidemiology, diagnosis, and management. J Gynecol Obstet Hum Reprod. 2020;49(9):101801. DOI: 10.1016/j.jogoh.2020.101801
4. Van der Meijden W.I., Boffa M.J., Ter Harmsel B. et al. 2021 European guideline for the management of vulval conditions. J Eur Acad Dermatol Venereol. 2022;36(7):952–972. DOI: 10.1111/jdv.18102
5. Henderson I., Lewis F., Williams A. et al. The diagnosis and management of vulval intraepithelial neoplasia. The Obstetrician & Gynaecologist. 2024;26:18–26. DOI: 10.1111/tog.12906
6. Kesić V., Vieira-Baptista P., Stockdale C.K. Early Diagnostics of Vulvar Intraepithelial Neoplasia. Cancers (Basel). 2022;14(7):1822. DOI: 10.3390/cancers14071822
7. Mehta S., Singla A. Preventive Oncology for the Gynecologist. Springer Nature Singapore Pte Ltd. 2019. DOI: 10.1007/978-981-13-3438-2
8. Morrison J., Baldwin P., Buckley L. et al. British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: Recommendations for practice. Eur J Obstet Gynecol Reprod Biol. 2020;252:502–525. DOI: 10.1016/j.ejogrb.2020.05.054
9. Committee Opinion No.675: Management of Vulvar Intraepithelial Neoplasia. Obstet Gynecol. 2016;128(4):e178–e182. DOI: 10.1097/AOG.0000000000001713. Erratum in: Obstet Gynecol. 2017;129(1):209. DOI: 10.1097/AOG.0000000000001839
10. Inayama Y., Yamanishi Y., Nakatani E. et al. Imiquimod for vaginal intraepithelial neoplasia 2–3: A systematic review and meta-analysis. Gynecol Oncol. 2021;160(1):140–147. DOI: 10.1016/j.ygyno.2020.09.031
11. Гинекология: национальное руководство. Под ред. Савельевой Г.М., Сухих Г.Т., Серова В.Н. и др. 2-е изд., испр. и доп. М.: ГЭОТАР-Медиа; 2022.Gynecology: a national guide. G.M. Savelyeva, G.T. Sukhikh, V.N. Serov et al., eds. 2nd ed., ispr. and add. M.: GEOTAR-Media, 2022 (in Russ.).
This work is licensed under a Creative Commons «Attribution» 4.0 License.
Распечатать