Expert Council: promising areas of systemic enzyme therapy in gynecology
DOI: 10.32364/2618-8430-2023-6-2-149-156
Yu.E. Dobrokhotova1, A.A. Khryanin2, E.V. Shikh3, L.Yu. Karakhalis4, I.M. Ordiyants5, E.A. Kogan1, A.V. Yakimova2, I.N. Korotkikh6, N.I. Kokhno7
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2Novosibirsk State Medical University, Novosibirsk, Russian Federation
3I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
4Russian University of Peoples' Friendship, Moscow, Russian Federation
5Kuban State Medical University, Krasnodar, Russian Federation
6N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation
7LLC “Center of Reproduction and Genetics”, Moscow, Russian Federation
The interdisciplinary scientific and practical conference «Expert Council: promising areas of systemic enzyme therapy (SET) in gynecology» under the auspices of the National Association of Obstetricians-Gynecologists and Reproductologists "Women's Health" was held in Moscow on December 02, 2022. The conference brought together specialists from multiple Russian regions. The development of effective treatment algorithms for infection-caused inflammatory diseases in the practices of obstetricians and gynecologists remains relevant in view of the continuous growth of antimicrobial resistance underpinned both by the irrational use of antibiotics and the biofilm-forming ability of infectious agents. The speakers shared their experience of using systemic enzyme therapy (SET) in the combination treatment of inflammatory diseases in obstetric and gynecological practice, as well as in the prevention of fibrous and adhesive complications of pelvic inflammatory diseases (PID) and gynecologic surgeries. It was pointed out that systemic enzyme therapy should be recognized as a justified component of the combination PID treatment which helps to reduce the duration and severity of symptoms due to its proven immunomodulatory, fibrinolytic and antiplatelet effects. The use of SET drugs reduces the duration of all stages of reparative regeneration along with tamping down the inflammatory response. The Expert Council Resolution provides recommendations on using SET in gynecology.
Keywords: proteolytic enzymes, pelvic inflammatory diseases, endometritis, adhesions, antibiotic resistance, systemic enzyme therapy.
For citation: Dobrokhotova Yu.E., Khryanin A.A., Shikh E.V. et al. Expert Council: promising areas of systemic enzyme therapy in gynecology. Russian Journal of Woman and Child Health. 2023;6(2):149–156 (in Russ.). DOI: 10.32364/2618-8430-2023-6-2-149-156.
About the authors:
Yuliya E. Dobrokhotova — Dr. Sc. (Med.), Professor, Head of the Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0002- 7830-2290.
Aleksey A. Khryanin — Dr. Sc. (Med.), Professor of the Department of Dermatovenerology and Cosmetology, Novosibirsk State Medical University; 52, Krasny av., Novosibirsk, 630091, Russian Federation; ORCID iD 0000-0001-9248-8303.
Evgeniya V. Shikh — Dr. Sc. (Med.), Director of the Institute of Professional Education, Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8, Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; ORCID iD 0000-0001-6589-7654.
Lyudmila Yu. Karakhalis — Dr. Sc. (Med.), Professor, Professor of the Department of Obstetrics, Gynecology and Perinatology, Kuban State Medical University; 4, Mitrofan Sedin str., Krasnodar, 350063, Russian Federation; ORCID iD 0000-0003-1040-6736.
Irina M. Ordiyants — Dr. Sc. (Med.), Professor, Professor of the Department of Obstetrics and Gynecology with Perinatology Course, Medical Institute, Russian University of Peoples' Friendship; 6, Miklukho-Maklaya str., Moscow, 117198, Russian Federation; ORCID iD 0000-0001-5882-9995.
Evgeniya A. Kogan — Dr. Sc. (Med.), Professor, Head of the Academician A.I. Strukov Department of Pathological Anatomy of the Faculty of Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8, Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; ORCID iD 0000-0002-1107-3753.
Anna V. Yakimova — Dr. Sc. (Med.), Professor of the Department of Obstetrics and Gynecology of the Faculty of Pediatrics, Novosibirsk State Medical University; 52, Krasny av., Novosibirsk, 630091, Russian Federation.
Irina N. Korotkikh — Dr. Sc. (Med.), Professor, Head of Department of Obstetrics and Gynecology No. 1, N.N. Burdenko Voronezh State Medical University; 10, Studencheskaya str., Voronezh, 394036, Russian Federation; ORCID iD 0000-0001-6525-5934.
Nelly I. Kokhno — C. Sc. (Med.), LLC “Center of Reproduction and Genetics”, 12, 3rd Parkovaya str., Moscow, 105043, Russian Federation.
Contact information: Yuliya E. Dobrokhotova, e-mail: pr.dobrohotova@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 05.03.2023.
Revised 29.03.2023.
Accepted 21.04.2023.
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