Prevention of obstetric complications 
E.G. Kudinova

Novosibirsk National Research University

Magnesium deficiency is accompanied by a threat of abortion, a decrease in fetoplacental blood flow and the development of placental insufficiency. Preventive use of magnesium preparations reduces the risk of possible complications of pregnancy and is effective for reducing the frequency of preeclampsia and miscarriage. The presented literature review provides the analysis of scientific publications in the international and Russian databases on the role of magnesium in preventing the complications of pregnancy. The results of the author’s own study on the magnesium exchange in women during pregnancy are presented. It is highlighted that the highest incidence rate of complications in pregnancy is identified in women with a magnesium deficiency, which have an unclassifiable phenotype of hereditary connective tissue disorders. It is shown that the replenishment of the magnesium deficiency during pregnancy planning has a favorable effect on its further course. The ways of magnesium deficiency correction, and the advantages of organic salts are shown. In this case, the combination of magnesium with orotic acid is used. The article substantiates the choice of magnesium orotate for the treatment of pregnant women, and considers the main indications for its use in obstetric practice.

Key words: magnesium, miscarriage, placental insufficiency, hemostasis system, collagen, unclassifiable phenotype of hereditary connective tissue disorders.
For citation: Kudinova E.G. Prevention of obstetric complications // RMJ. 2017. № 26. P.1952 –1957.