Features of candida colpitis treatment
Tikhomirov A.L.¹, Sarsania S.I.², Manukhin I.B.¹, Kazenashev V.V.¹, Tuskayev K.S.², Yudina Т.A.<sup>3

1</sup> Moscow State Medical Stomatological University named after А.I. Evdokimov
² Federal Center for Reproduction “Santa Maria”, Moscow
³ Multidisciplinary medical holding company "SM-Clinic", Moscow

The feature of candida colpitis (CC) is its high frequency, the prolonged course, frequent recurrence, the possibility of spreading to other organs and systems with the development of generalized forms of candidiasis, high resistance of pathogens to antimycotic drugs, difficulties in applying the therapy in pregnant women. CC accounts for 30-45% of the vaginal and vulval infections. The paper presents the pathogenesis and clinical picture of the three forms of CC: carriage of candidosis, acute form of CC, chronic (recurrent) CC. The issue of CC therapy and the problem of resistance to this therapy is highlighted. Fungistatic, not fungicidal, mechanism of action of drugs predetermines the possibility of developing resistance to antimycotics. An important task is to use the most effective antimycotics with an adequate spectrum of action to exclude possible relapses after treatment of acute CC. The drug of choice is sertaconazole (benzothiophene and imidazole derivative) because it is an effective antimycotic with an adequate spectrum of action and the possibility of convenient use (once for a course of treatment) is. The drug meets all the necessary requirements of antimycotics for the CC treatment, it is convenient to use (1 vaginal suppository for treatment) and is safe in clinical practice.

Key words: candida colpitis, resistance to antimycotics, fungicidal effect of sertaconazole, antimicrobial and anti-erythematous activity, Zalain^®.
For citation: Tikhomirov A.L., Sarsania S.I., Manukhin I.B. et al. Features of candida colpitis treatment // RMJ. 2017. № 26. P. 1977–1982.