Genital endometriosis: pathogenesis, diagnosis, and association with malignancies
DOI: 10.32364/2618-8430-2021-4-4-339-345
I.Yu. Il’ina1, D.V. Burdin2, M.R. Narimanova1, D.M. Ibragimova1
1Pirogov Russian National Research Medical University, Moscow, Russian Federation
2N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation
Endometriosis is a hormone-dependent genetic disease that develops in impaired immune homeostasis. However, its pathogenesis remains an enigma. It is known that eutopic endometrium in women with endometriosis is different from that in healthy women. Morphologic examination of eutopic endometrium sample allows diagnosing endometriosis at an early stage. To date, the association between endometriosis and the risk of malignancies is in strong focus. Endometriosis is a benign disorder but shares similarities with malignancies, e.g., apoptosis resistance and stimulation of angiogenesis. Recent findings suggest that endometriosis is a precursor of clear cell and endometrioid ovarian cancer. Further studies are needed to identify novel markers of endometriosis for its timely diagnosis. Timely and adequate therapy reduces the prevalence of ovarian tumors. Further development of molecular studies on endometriosis and ovarian cancer predictors will uncover pathogenic mechanisms and find potential preventive and treatment modalities.
Keywords: endometriosis, ovarian cancer, eutopic endometrium, ectopic endometrium, apoptosis, angiogenesis.
For citation: Il’ina I.Yu., Burdin D.V., Narimanova M.R., Ibragimova D.M. Genital endometriosis: pathogenesis, diagnosis, and association with malignancies. Russian Journal of Woman and Child Health. 2021;4(4):339–345 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-339-345.
About the authors:
Irina Yu. Il’ina — Dr. Sc. (Med.), professor of the Department of Obstetrics and Gynecology of the Medical Faculty, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0001-8155-8775.
Dmitriy V. Burdin — obstetrician gynecologist, N.I. Pirogov City Clinical Hospital No. 1; 8, Leninskiy av., Moscow, 119049, Russian Federation; ORCID iD 0000-0001-8050-6543.
Metanat R. Narimanova — C. Sc. (Med.), assistant of the Department of Obstetrics and Gynecology of the Medical Faculty, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0003-0677-2952.
Dzhamilya M. Ibragimova — C. Sc. (Med.), associate professor of the Department of Obstetrics and Gynecology of the Medical Faculty, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0002-8738-868Х.
Contact information: Irina Yu. Il’ina, e-mail: iliyina@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 05.10.2021.
Revised 28.10.2021.
Accepted 24.11.2021.
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