Problems of treatment of opisthorchiasis
Plotnikova E.Yu., Baranova Е.N.
Kemerovo State Medical University Ministry
Opisthorchiasis is a natural focal zooanthroponosis. Opisthorchiasis is caused by helminths related to the Plathelmintes type, the Trematoda class, the Opisthorchidae family, Opisthorchis felineus and Opisthorchis viverrini species. The largest and most tense center of opisthorchosis in the world is Ob-Irtysh region, covering 10 districts and regions of Russia and Kazakhstan. Invasive population of Opisthorchis felineus in Western Siberia reaches 51.82%, in some areas over 95%. The course of opisthorchiasis can be acute and chronic. The clinical picture of the infection depends on the number of pathogens, with a small number of parasites the disease can be mild or asymptomatic, which can lead to a missed or late diagnosis. In fact, these parasites can not reproduce in the human body, and therefore the intensity of infestation with a high frequency of outbreaks can only be achieved by re-consuming the infected fish. Timely diagnosing is very important because the untreated opisthorchiasis invasion can lead to serious complications, such as liver cirrhosis, hepatocellular carcinoma and others. The article describes the case of liver cirrhosis of opisthorchiasis etiology, tactics of treatment of this severe complication and the results of dehelminthization. The problems of the absence of an anti-opisthorchiasis drug in Russia are discussed and alternative ways of solving this problem are proposed.
Key words: opisthorchiasis, Opisthorchis felineus, liver cirrhosis, Praziquantel, Albendazole.
For citation: Plotnikova E.Yu., Baranova Е.N. Problems of treatment of opisthorchiasis // RMJ. Medical Review. 2018. № 3. P. 53–56.
References
1. Fürst T., Keiser J., Utzinger J. Global burden of human food-borne trematodiasis: a systematic review and meta-analysis // Lancet Infect Dis. 2012. Vol. 12. P. 210–221.
2. Toledo R., Esteban J. G., Fried B. Current status of food-borne trematode infections // Eur J Clin Microbiol Infect Dis. 2012. Vol. 31. P. 1705–1718.
3. Pozio E., Armignacco O., Ferri F., Gomez Morales M. A. Opisthorchis felineus, an emerging infection in Italy and its implication for the European Union // Acta Trop. 2013. Vol.126. P. 54–62.
4. Яблоков Д. Д. Описторхоз человека. Томск, 1979. 237 с. [Yablokov D. D. Opistorkhoz cheloveka. Tomsk, 1979. 237 s. (in Russian)].
5. Armignacco O., Ferri F., Gomez Morales M. A. et al. Cryptic and Asymptomatic Opisthorchis felineus Infections // Am J Trop Med Hyg. 2013. Vol. 88 (2). P. 364–366.
6. Schuster R. K. Opisthorchiidosis – a review // Infect Disord Drug Targets. 2010. Vol. 10. P. 402–415.
7. Mordinov V. A., Furman D. P. The Digenea parasite Opisthorchis felineus: a target for the discovery and development of novel drugs // Infect Disord Drug Targets. 2010. Vol. 10. P. 385–401.
8. Клиника, диагностика и лечение описторхоза (методические рекомендации). М., 1989. 15 с. [Klinika, diagnostika i lecheniye opistorkhoza (metodicheskiye rekomendatsii). Moskva, 1989. 15 s. (in Russian)]. (Электронный ресурс). URL: https://hepatolog72.ru/articl/Clinic-diagnosis-and-treatment-opistorhoza-Moscow-1989.pdf. (Дата обращения: 28.03.2018).
9. Клинические рекомендации (протокол лечения) оказания помощи детям, больным описторхозом [Klinicheskiye rekomendatsii (protokol lecheniya) okazaniya pomoshchi detyam, bol’nym opistorkhozom (in Russian)]. (Электронный ресурс). URL: http://niidi.ru/dotAsset/ebd00542-c9ea-438b-9dd9–389358028752.pdf. (Дата обращения: 28.03.2018).
10. Описторхоз у взрослых. Клинические рекомендации [Opistorkhoz u vzroslykh. Klinicheskiye rekomendatsii (in Russian)]. (Электронный ресурс). URL: http://nnoi.ru/uploads/files/protokoly/Opistorchoz_adult.pdf. (Дата обращения: 28.03.2018).
11. Gouveia M. J., Pakharukova M., Laha T. et al. Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model // Carcinogenesis. 2017. Vol. 38 (9). P. 929–937.
12. Armignacco O., Caterini L., Marucci G. et al. Human illnesses caused by Opisthorchis felineus flukes, Italy // Em Infect Dis. 2008. Vol. 14. P. 1902–1905.
13. Traverso A., Repetto E., Magnani S. et al. A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome // Eur J Clin Microbiol Infect Dis. 2012. Vol. 31. P. 1089–1093.
14. Crotti D., D’Annibale M.L., Crotti S. Opistorchiasi autoctona del Lago Trasimeno (Perugia): descrizione di due episodi epidemici da Opisthorchis felineus e problematiche diagnostiche differenziali // Microbiologia Medica. 2007. Vol. 42. P. 36–41.
15. Murell K. D., Pozio E. The Liver Flukes: Clonorchis sinensis, Opisthorchis spp, and Metorchis spp. (Электронный ресурс). URL: http://www.waterpathogens.org/book/liver-flukes. (Дата обращения: 28.03.2018).
16. Государственный реестр лекарственных средств [Gosudarstvennyy reyestr lekarstvennykh sredstv (in Russian)]. (Электронный ресурс). URL: https://grls.rosminzdrav.ru/GRLS.aspx? RegNumber=&MnnR=%D0%90%D0%BB%D0%B1%D0%B5%D0%BD%D0%B4%D0%B0%D0%B7%D0%BE%D0%BB&lf=&TradeNmR=&OwnerName=&MnfOrg=&MnfOrgCountry=&isfs=0&isND= –1®type=&pageSize=10&order=RegDate&orderType=desc&pageNum=1. (Дата обращения: 28.03.2018).
This work is licensed under a Creative Commons «Attribution» 4.0 License.
Previous article
Next article
Распечатать