Autoimmune gastritis: diagnosis to effective therapy
DOI: 10.32364/2587-6821-2024-8-5-9
S.V. Shchelochenkov1,2, D.S. Bordin3–5, M.V. Chebotareva3, M.A. Lisovsky2, A.V. Gubanova2, O.N. Guskova5
1Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
2Omsk State Medical University, Omsk, Russian Federation
3A.S. Loginov Moscow Clinical Research Center, Moscow, Russian Federation
4Russian University of Medicine, Moscow, Russian Federation
5Tver State Medical University, Tver, Russian Federation
In recent decades, there has been a tendency to decrease the Helicobacter pylori (HP) infection proportion in the structure of etiological factors concerning the chronic gastritis, which, on the one hand, was due to the success of eradication therapy, and on the other hand, due to a decrease in the number of new infections. At the same time, there is an increase in the importance of other disease causes, which were previously considered extremely rare, as well as a combined etiology, primarily with HP infection. Currently, international position papers attract the attention of clinicians to an increase in the autoimmune gastritis (AIG) prevalence in the adult population. Besides, in real clinical practice, AIG is commonly diagnosed at the stage of severe atrophy and formed macro and micro-nutrient deficiencies, requiring correction of nutritional status to prevent the development of significant neurological disorders, anemia syndrome, as well as osteopenia/osteoporosis. The presented article is aimed at drawing the practitioner's attention to possible morphological predictors of the disease and the difficulties in the diagnostic search for AIG that may arise during differential diagnosis, including if AIG is combined with HP infection, as well as when choosing effective pharmacotherapy.
Keywords: autoimmune gastritis, atrophic gastritis, Helicobacter pylori infection, gastroprotection, carcinoprevention, rebamipid.
For citation: Shchelochenkov S.V., Bordin D.S., Chebotareva M.V., Lisovsky M.A., Gubanova A.V., Guskova O.N. Autoimmune gastritis: diagnosis to effective therapy. Russian Medical Inquiry. 2024;8(5):299–306 (in Russ.). DOI: 10.32364/2587-6821-2024-8-5-9.
ABOUT THE AUTHORS:
Sergey V. Shchelochenkov — C. Sc. (Med.), Associate Professor of the Department of Therapy of the Institute of Medicine and Life Sciences, Immanuel Kant Baltic Federal University; 14, A. Nevskii str., Kaliningrad, 236016, Russian Federation; Associate Professor of the Department of Faculty Therapy and Gastroenterology, Omsk State Medical University; 12, Lenin str., Omsk, 644099, Russian Federation; ORCID iD 0000-0002-3811-2492.
Dmitry S. Bordin — Dr. Sc. (Mеd.), Head of the Department of Pathology of the Pancreas, Biliary Tract and Upper Digestive Tract, A.S. Loginov Moscow Clinical Research Center; 86, Entuziastov road, Moscow, 111123, Russian Federation; Professor of the Department of Propaedeutics of Internal Diseases and Gastroenterology, Russian University of Medicine; 20, build. 1, Delegatskaya str., Moscow, 127473, Russian Federation; Professor of the Department of General Medical Practice and Family Medicine, Tver State Medical University; 4, Sovetskaya str., Tver, 170100, Russian Federation; ORCID iD 0000-0003-2815-3992.
Margarita V. Chebotareva — specialist of the Organizational and Methodological Department of Gastroenterology Moscow Health Department, Junior Researcher at the Laboratory of Functional Diagnostics of the Esophagus and Stomach Diseases, A.S. Loginov Moscow Clinical Research Center; 86, Entuziastov road, Moscow, 111123, Russian Federation.
Maxim M. Lisovskiy — resident of the Department of Faculty Therapy and Gastroenterology, Omsk State Medical University; 12, Lenin str., Omsk, 644099, Russian Federation; ORCID iD 0000-0001-9674-0545.
Anastasia V. Gubanova — gastroenterologist, Assistant Professor of the Department of Faculty Therapy and Gastroenterology, Omsk State Medical University; 12, Lenin str., Omsk, 644099, Russian Federation.
Oksana N. Guskova — C. Sc. (Med.), Head of the Department of Pathological Anatomy, Tver State Medical University; 4, Sovetskaya str., Tver, 170100, Russian Federation; ORCID iD 0000-0003-1635-7533.
Contact information: Sergey V. Shchelochenkov, e-mail: workmedbox@gmail.com.
Financial Disclosure: the authors have no financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 05.04.2024.
Revised 30.04.2024.
Accepted 28.05.2024.
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