Non-alcoholic fatty liver disease – relationships with metabolic syndrome
A.Yu. Babenko, M.Yu. Laevskaya

National Medical Research Centre named after V.A. Almazov, Saint-Petersburg

The continuous parallel increase in the number of people suffering from metabolic syndrome and non-alcoholic fatty liver disease indicates a close pathogenetic relationship of these pathologies. Therefore it is necessary to form approaches to the treatment of the latter, taking into account various components of the metabolic syndrome. The review considers both the pathogenetic relationships of non-alcoholic fatty liver disease and metabolic syndrome as well as current trends in diagnosis and treatment. The summary of information on the leading risk factors for non-alcoholic fatty liver disease clearly demonstrates the key role of various manifestations of the metabolic syndrome in it’s development. The importance of correction of various manifestations of the metabolic syndrome as the main method of preventing non-alcoholic fatty liver disease is pointed out. Modern diagnostic algorithms using the innovative non-invasive techniques are presented. The possibilities of personalization of treatment approaches are indicated depending on the presence or absence of violations of carbohydrate metabolism and the stage of liver damage. The place of bariatric surgery as a personalized approach to the treatment of patients with morbid forms of obesity is defined. Finally, the prospects for further development of methods for treating non-alcoholic fatty liver disease are discussed.

Key words: non-alcoholic fatty liver disease, obesity, metabolic syndrome, fibrosis markers, fibrosis score, glitazones, еssential phospholipids.
For citation: Babenko A.Yu., Laevskaya M.Yu. Non-alcoholic fatty liver disease – relationships with metabolic syndrome // RMJ. 2018. № 1 (I). P. 34–40.