Case report of a severe course of Cushing's disease
DOI: 10.32364/2587-6821-2023-7-9-8
N.P. Gorbunova1, G.V. Prokhorova2, A.S. Zubkova1, S.M. Korotkikh3, A.P. Volynkina4, Ya.Ya. Reshetnyak5
1Lipetsk Regional Clinical Hospital, Lipetsk, Russian Federation, Lipetsk, Russian Federation
2Medical Surgical Clinics "Andromeda", Lipetsk, Russian Federation
3Lipetsk City Polyclinics No. 1, Lipetsk, Russian Federation
4N.N. Burdenko Voronezh State Medical University, Voronezh, Russian Federation
5Lipetsk City Hospital of Emergency Care No. 1, Lipetsk, Russian Federation
Cushing's disease is a severe neuroendocrine disorder caused by excessive release of adrenocorticotropic hormone by pituitary tumor. The rate is 39.1 per 1 million and the incidence is 1.2–2.4 per 1 million. Typical symptoms include rapid weight gain associated with muscle weakness, hypertension, diabetes, and osteoporosis. The key diagnostic tool is brain MRI after laboratory confirmation of a diagnosis of hypercortisolemia. The key treatment is transsphenoidal adenomectomy, which provides remission in 65–90% of patients. This paper describes the severe course of Cushing's disease in a male patient, which has long remained undiagnosed. Diagnostic search steps, differential diagnostic difficulties, and follow-up results (including inferior petrosal sinus sampling) are discussed. A multidisciplinary approach and teamwork ensure timely diagnosis, prevent complications of Cushing's disease, and improve prognosis and quality of life.
Keywords: Cushing's disease, case report, hypercortisolism, hypercortisolemia, ACTH, somatostatin receptor scintigraphy, transsphenoidal adenomectomy.
For citation: Gorbunova N.P., Prokhorova G.V., Zubkova A.S., Korotkikh S.M., Volynkina A.P., Reshetnyak Ya.Ya. Case report of a severe course of Cushing's disease. Russian Medical Inquiry. 2023;7(9):606–610 (in Russ.). DOI: 10.32364/2587-6821-2023-7-9-8.
About the authors:
Natal'ya P. Gorbunova — Chief Freelance Endocrinologist of the Lipetsk Region, Head of the Center "Diabetes" of the Lipetsk Regional Clinical Hospital; 6A, Moskovskaya str., Lipetsk, 398055, Russian Federation; ORCID iD 0000-0002-6983-966X.
Galina V. Prokhorova — endocrinologist, LLC Medical Surgical Clinics "Andromeda"; 10A, Kuznechnaya str., Lipetsk, 398050, Russian Federation.
Anastasiya S. Zubkova — Head of the Endocrinological Department, Lipetsk Regional Clinical Hospital; 6A, Moskovskaya str., Lipetsk, 398055, Russian Federation.
Svetlana M. Korotkikh — endocrinologist, Lipetsk City Polyclinics No. 1; 26, Sovetskaya str., Lipetsk, 398001, Russian Federation; ORCID iD 0000-0001-6866-7707.
Anna P. Volynkina — C. Sc. (Med.), Associate Professor, associate professor of the Department of Hospital Therapy and Endocrinology, N.N. Burdenko Voronezh State Medical University; 10, Studencheskaya str., Voronezh, 394036, Russian Federation; ORCID iD 0000-0001-8942-6224.
Yana Ya. Reshetnyak — Head of the Endocrinological Department, Lipetsk City Hospital of Emergency Care No. 1; 39, Kosmonavtov str., Lipetsk, 398035, Russian Federation; ORCID iD 0009-0003-8260-0922.
Contact information: Svetlana M. Korotkikh, e-mail: sve.korotki@yandex.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 27.02.2023.
Revised 21.03.2023.
Accepted 11.04.2023.
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