Current markers during the onset of carbohydrate metabolism disorders

A.V. Gordienko, A.S. Fedorova, D.Yu. Serdyukov

Kirov Military Medical Academy, Saint Petersburg

For several decades, there has been a increase in the prevalence of dysglycemia and type 2 diabetes mellitus (DM2) in patients with verified cardiovascular diseases. The number of patients with chronic hyperglycemia is doubling every decade, whereas with DM2 — up to 95% of all new cases. This fact explains the priority of primary prevention of DM and the risk of cardiovascular complications. Identification of markers concerning carbohydrate metabolism early disorders remains extremely relevant today. At present, commonly used indicators (e.g. pre-diabetes impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT)) do not solve the issue of effective diagnosis concerning carbohydrate metabolism disorders, which actualizes the search for new markers. Results of large-scale research studies suggest that the reason is associated with glycemia increase after 1 hour or with the so-called one -hour (early) postprandial hyperglycemia (EPH), determined after the initiation of the oral glucose tolerance test (OGTT) at plasma glucose level ≥ 8.6 mmol/l (155 mg/dl).

Keywords: one-hour postprandial hyperglycemia, prediabetes, oral glucose tolerance test, risk marker, cardiovascular diseases, type 2 diabetes mellitus.

For citation: Gordienko A.V., Fedorova A.S., Serdyukov D.Yu. Current markers during the onset of carbohydrate metabolism disorders. RMJ. 2020;1:35–38.