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Folded pachydermia associated with hair transplantation (case reports)

Abstract

DOI: 10.32364/2587-6821-2026-10-6-15

Folded pachydermia associated with hair transplantation (case reports)

V.V. Gladko^1, G.A. Flaks¹, R.A. Pakhomova¹, A.A. Kolesnik¹, V.Ya. Kolesnik¹, V.A. Ivanova²

¹ ROSBIOTECH, Moscow, Russian Federation

² Russian University of Medicine, Moscow, Russian Federation

Folded pachydermia of the scalp is a rare benign condition characterized by skin hypertrophy and formation of pronounced folds. Despite the description of primary and secondary forms of the disease, an impact of surgical interventions — particularly hair transplantation — on the onset or progression of pachydermia is still underinvestigated.

Two clinical case reports of patients with androgenetic alopecia who underwent follicular unit extraction (FUE) hair transplantation are presented. In one case, transplantation was performed in the parietal region, while in the other it was limited to the fronto-parietal area. Dynamic follow-up including clinical and visual assessment of the scalp skin condition was carried out for 6 months. In both cases, localized enhancement of scalp skin folding that corresponded to the surgical site was reported after hair transplantation. No progression of folded skin changes was detected in intact regions of the scalp or in the occipital donor area where graft harvesting was performed. The obtained data suggest that hair transplantation may act as a trigger for development or exacerbation of folded pachydermia in predisposed patients. Mechanical skin trauma, microcirculatory disturbances, and local inflammatory response are likely to play a key role in the pathogenesis of this condition. The findings highlight the importance of thorough preoperative assessment of the scalp skin and informing patients about potential risks.

Keywords: folded pachydermia, hair transplantation, FUE, androgenetic alopecia.

For citation: Gladko V.V., Flaks G.A., Pakhomova R.A., Kolesnik A.A., Kolesnik V.Ya., Ivanova V.A. Folded pachydermia associated with hair transplantation (case reports). Russian Medical Inquiry. 2026;10(6):–438 (in Russ.). DOI: 10.32364/2587-6821-2026-10-6-15

About the authors:

Viktor V. Gladko — Dr. Sc. (Med.), Professor, Head of the Department of Skin and Venereal Diseases with a Cosmetology Course of the Medical Institute of Continuing Education, ROSBIOTECH; 11, Volokolamskoe road, Moscow, 125080, Russian Federation; ORCID iD 0000-0002-2173-4383

Grigoryi A. Flaks — Dr. Sc. (Med.), Professor, Professor of the Department of Skin and Venereal Diseases of the Medical Institute of Continuing Education, ROSBIOTECH; 11, Volokolamskoe road, Moscow, 125080, Russian Federation; ORCID iD 0009-0007-3298-3389

Regina A. Pakhomova — Dr. Sc. (Med.), Associate Professor, Head of the Department of Plastic Surgery of the Medical Institute of Continuing Education, ROSBIOTECH; 11, Volokolamskoe road, Moscow, 125080, Russian Federation; ORCID iD 0000-0002-3681-4685

Vasilyi Ya. Kolesnik — Postgraduate Student at the Department of Plastic Surgery of the Medical Institute of Continuing Education, ROSBIOTECH; 11, Volokolamskoe road, Moscow, 125080, Russian Federation; ORCID iD 0009-0001-6572-2392

Anastasia A. Kolesnik — Postgraduate Student at the Department of Plastic Surgery of the Medical Institute of Continuing Education, ROSBIOTECH; 11, Volokolamskoe road, Moscow, 125080, Russian Federation; ORCID iD 0009-0002-9999-4107

Victoria A. Ivanova — 6th-year Student, Russian University of Medicine; 4, Dolgorukovskaya str., Moscow, 127006, Russian Federation; ORCID iD 0009-0008-4193-2548

Contact information: Vasilyi Ya. Kolesnik, e-mail: v.kolesnik@bk.ru

Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.

There is no conflict of interest.

Received 10.06.2026.

Revised 19.06.2026.

Accepted 30.06.2026.

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