Adjuvant topical therapy in psoriasis
A.L. Bakulev, S.S. Kravchenya, I.A. Igonina, E.M. Galkina, S.R. Utz
Saratov State Medical University named after V.I. Razumovsky
Aim: to evaluate Cetaphil® Restoraderm™ use effectiveness in complex treatment of patients suffering from moderate-to-severe psoriasis.
Patients and Methods: 60 adult patients of both sexes with the moderate-to-severe psoriasis were examined in a phase of dermatosis progression. Indices PASI, DLQI, indices of itch intensity, as well as greasiness, moisture and elasticity of the skin were evaluated in these patients. In a composition of complex therapy with methotrexate and topical glucocorticosteroid (tGCS), the cosmetic product Cetaphil® Restoraderm™ — skin regenerating moisturizing lotion — was additionally used by the patients.
Results and Discussion: inclusion of the moisturizing cosmetic product Cetaphil® Restoraderm™ in the complex therapy resulted in earlier stabilization and regression of the psoriatic process, as well as in improving quality of life and helped to reduce skin dryness, normalize skin moisture and elasticity. By the 14th day of the therapy, positive dynamics of the psoriatic process was observed in all groups — a decrease in the PASI index (p <0.05), the most pronounced in patients who used the tGCS and Cetaphil® Restoraderm™ throughout the course of therapy. At the end of the therapy, similar data was obtained in patients who used betamethasone dipropionate for entire 28 days, and in patients treated from 14-day to 28-day with the tGCS and moisturizing cosmetic product Cetaphil® Restoraderm™.
Conclusions: cytostatic therapy with combined use of the corticosteroids and moisturizing cosmetic agent contributes to onset of an earlier effect and is able to significantly shorten the treatment period for the patients suffering from psoriasis. The inclusion of cosmetic product Cetaphil® Restoraderm™ — skin regenerating moisturizing lotion — in the daily care in the patients with moderate-to-severe plaque psoriasis during the phase of dermatosis progression contributes to optimization of the therapy and also has a pronounced seborrhagulatory, elastogenic and moisturizing effect.
Key words: psoriasis, adjuvant therapy, effectiveness, safety, Cetaphil® Restoraderm™.
For citation: Bakulev A.L., Kravchenya S.S., Igonina I.A. et al. Adjuvant topical therapy in psoriasis // RMJ. Medical Review. 2018. № 5. P. 55–59.
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