Mast cells in allergic and infectious inflammation
DOI: 10.32364/2587-6821-2022-6-2-79-84
N.V. Kolesnikova
Kuban State Medical University, Krasnodar, Russian Federation
Functional characteristics of a heterogeneous population of innate immune cells, mast cells, account for their involvement in many inflammatory and autoimmune diseases and tumors. A diversity of mast cell receptors and secreted biologically active mediators, broad presence in barrier tissues, and close relation with blood and lymphatic vessels allow mast cells to realize many protective functions (including as effective participants of allergic reactions and primary effectors of the immune response to infections). The primary role of mast cells in immune-mediated inflammation is accounted for by the synthesis and secretion of numerous biologically active substances under their activation with various factors (e.g., allergens, cytokines, anaphylotoxins, neuropeptides, immune complexes, microbial antigens and toxins, some medications). Impaired regulation of mast cell functions may have a negative effect which determines a pattern of their involvement in the pathogenesis of chro nic allergic, inflammatory, and autoimmune diseases and tumors. Despite a better understanding of the pathogenic role of mast cells in immune-mediated inflammatory disorders, studies on the mechanisms of their activation and regulation, pattern and im-portance of the interaction of their mediators with immune cells, and mechanisms of the implementation of mast cell pro-inflammatory effects are still relevant. The results of these studies are likely to optmise the treatment of a variety of diseases.
Keywords: mast cells, immune pathogenesis, mediators, allergic inflammation, infectious inflammation, atopic dermatitis.
For citation: Kolesnikova N.V. Mast cells in allergic and infectious inflammation. Russian Medical Inquiry. 2022;6(2):79–84 (in Russ.). DOI: 10.32364/2587-6821-2022-6-2-79-84.
About the author:
Natalya V. Kolesnikova — Dr. Sc. (Biol.), professor of the Department of Clinical Immunology, Allergy, and Lab Diagnostics of the Faculty of Advanced Training and Vocational Retraining of Specialists, Kuban State Medical University; 4, Mitrofan Sedin str., Krasnodar, 350063, Russian Federation; ORCID iD 0000-0002-9773-3408.
Contact information: Natalya V. Kolesnikova, e-mail: nvk24071954@mail.ru.
Financial Disclosure: the author has no a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 07.02.2022.
Revised 03.03.2022.
Accepted 30.03.2022.
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