Complex clinical case: hereditary angioedema
DOI: 10.32364/2587-6821-2021-5-1-50-53
E.A. Sobko1,2, I.V. Demko1,2, I.A. Solovieva1,2, A.Yu. Kraposhina1,2, N.V. Gordeeva1,2, D.A. Anikin1
1Krasnoyarsk State Medical University named after Prof. Voino-Yasenetsky,
Krasnoyarsk, Russian Federation
2Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk, Russian Federation
Nowadays, isolated angioedema is one of the most complex and urgent problems of modern allergology and immunology. Hereditary angioedema (HA) refers to orphan and life-threatening diseases associated with a deficiency or decrease in C1-inhibitor function and
is characterized by recurrent edema in deep dermis of various localization. A doctor of any specialty can encounter this nosology, which obliges all medical officers to have a general overview concerning HA. Late diagnosis is fraught with unnecessary surgical interventions, psychological symptoms, opiate addiction, or life-threatening laryngeal angioedema. To date, the final diagnosis of HA, and, consequently, adequate drug therapy, is delayed by an average of 8.5 years from disease onset. Sudden edema in the vital organs is a source of constant anxiety, a cause of disability, and sometimes fatal outcomes. The article presents a clinical case and discusses therapy principles, existing possibilities of promising tr eatment and recommendations for further management.
Keywords: hereditary angioedema, recurrent edema, orphan diseases, bradykinin; C1-inhibitor; complement system.
For citation: Sobko E.A., Demko I.V., Solovieva I.A. et al. Complex clinical case: hereditary angioedema. Russian Medical Inquiry. 2021;5(1):50–53. DOI: 10.32364/2587-6821-2021-5-1-50-53.
Acknowledgement
Editorial Board is grateful to Takeda Russia for the assistance in technical edition of this publication.
About the authors:
Elena A. Sobko — Dr. of Sci. (Med.), Associate Professor, Professor of Department of Internal Diseases and Immunology with Postgraduate Education course, Krasnoyarsk State Medical University named after Prof. Voino-Yasenetsky; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; Head of the Department of Allergology, Krasnoyarsk Regional Clinical Hospital; 3A, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0002-9377-5213.
Irina V. Demko — Dr. of Sci. (Med.), Professor, Head of the Department of Internal Diseases and Immunology with Postgraduate Education course, Krasnoyarsk State Medical University named after Prof. Voino-Yasenetsky; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; Head of the Pulmonary and Allergy Center, Krasnoyarsk Regional Clinical Hospital; 3A, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0001-8982-5292.
Irina A. Solovieva — Dr. of Sci. (Med.), Associate Professor of the Department of Internal Diseases and Immunology with Postgraduate Education course, Krasnoyarsk State Medical University named after Prof. Voino-Yasenetsky; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; pulmonologist, Krasnoyarsk Regional Clinical Hospital; 3A, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0002-1999-9534.
Angelina Yu. Kraposhina — Cand. of Sci. (Med.), Associate Professor of the Department of Internal Diseases and Immunology with Postgraduate Education course, Krasnoyarsk State Medical University named after Prof. Voino-Yasenetsky; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; pulmonologist, Krasnoyarsk Regional Clinical Hospital; 3A, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0001-6896-877X.
Natalia V. Gordeeva — Cand. of Sci. (Med.), Associate Professor of the Department of Internal Diseases and Immunology with Postgraduate Education course, Krasnoyarsk State Medical University named after Prof. Voino-Yasenetsky: 1, Partizana Zheleznyaka str., Krasnoyarsk; 660022, Russian Federation; pulmonologist, Krasnoyarsk Regional Clinical Hospital; 3A, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0002-0586-8349.
Dmitriy A. Anikin — resident of the Department of Internal Diseases and Immunology with Postgraduate Education course, Krasnoyarsk State Medical University named after Prof. Voino-Yasenetsky; 1, Partizana Zheleznyaka str., Krasnoyarsk, 660022, Russian Federation; ORCID iD 0000-0002-1598-436X.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 03.08.2020, revised 27.08.2020, accepted 07.09.2020.
2. Federal clinical guidelines for the diagnosis and treatment of patients with angioedema. Russian Association of Allergologists and Clinical Immunologists. M.; 2013 (in Russ.).
3. Davis A.E. Mechanism of angioedema in first complement component inhibitor deficiency. Immunol Allergy Clin North Am. 2006;26(4):633–651.
4. Bhardwaj N., Craig T.J. Treatment of hereditary angioedema: a review (CME). Transfusion. 2014;54(11):2989–2996.
5. Patel N., Suarez L.D., Kapur S., Bielory L. Hereditary angioedema and gastrointestinal complications: an extensive review of the literature. Case Reports Immunol. 2015;2015:925861.
6. Salemi M., Bella F.D., Miragliotta A. et al. Psychological correlates in subjects with hereditary angioedema (HAE). J Psychol Psychother. 2014;4:134.
7. Fouche A.S., Saunders E.F., Craig T. Depression and anxiety in patients with hereditary angioedema. Ann Allergy Asthma Immunol. 2014;112(4):371–375.
8. Federal clinical guidelines for the diagnosis and treatment of patients with angioedema. Russian Association of Allergologists and Clinical Immunologists. M.; 2014 (in Russ.).
9. Latysheva T.V., Latysheva E.A., Manto I.A. Short-term prophylaxis of hereditary angioedema. RMJ. 2018;8(I):53–58 (in Russ.).
10. Maurer M., Magerl M., Ansotegui I. et al The international WAO/EAACI guideline for the management of hereditary angioedema — The 2017 revision and update. Allergy. 2018;73(8):1575–1596. DOI: 10.1111/all.13384.
11. Nikolaeva S.S. Diagnosis and treatment of hereditary angioedema in pregnancy and childbirth. Sibirskiy meditsinskiy zhurnal (Irkutsk). 2019;156(1):43–45 (in Russ.).
12. Filippova A., Malova I.O., Khashkina L.A. et al. Angioedema: anamnestic and clinical laboratory relations. RMJ. Medical Review. 2019;12:4–8.
13. Bork K., Aygoeren-Pürsün E., Baş M. et al. Guideline: Hereditary angioedema due to C1 inhibitor deficiency. Allergo J Int. 2019;28:16–29.
This work is licensed under a Creative Commons «Attribution» 4.0 License.
Распечатать