Pharmacological optimization of antihistamine profile
DOI: 10.32364/2587-6821-2022-6-2-92-97
E.N. Kareva
I.M. Sechenov First Moscow State Medical University (Sechenov University),
Moscow, Russian Federation
Pirogov Russian National Research Medical University, Moscow, Russian Federation
Antihistamines are the first-line treatment for allergic diseases. The optimization of pharmacological properties of these pharmacotherapeutics is provided by the synthesis of new molecules with better safety profile (no penetration via the blood-brain barrier or less risk of drug interactions) or more selective affinity to H1-receptors (active optical isomer). In real clinical practice, drugs with extrahepatic metabolism have an advantage, the effectiveness of which does not depend on concomitant therapy, and the maximum concentration is reached in the shortest possible time, which ensures a rapid onset of action. Comfort use and, therefore, adherence to treatment is also an essential aspect of pharmacotherapy. Current orodispersible H1-receptor antagonists have a clinically significant antihistamine effect and agree with patient expectations due to comfort use and no need to take them with water. As a result, these medications are suitable for specific categories of individuals, e.g., children, patients with difficulty of swallowing, and people practicing an active lifestyle.
Keywords: histamine, antihistamines, levocetirizine, pharmacokinetics, pharmacodynamics, orodispersible forms, compliance.
For citation: Kareva E.N. Pharmacological optimization of antihistamine profile. Russian Medical Inquiry. 2022;6(2):92–97 (in Russ.). DOI: 10.32364/2587-6821-2022-6-2-92-97.
Acknowledgments
The technical edition is supported by LLC "Dr. Reddy’s Laboratories".
About the author:
Elena N. Kareva — Dr. Sc. (Med.), professor of the Department of Pharmacology, Institute of Biodesign and Modeling of Complex Systems, I.M. Sechenov First Moscow State Medical University (Sechenov University); 13, Nikitskiy Blvd., Moscow, 119019, Russian Federation; professor of the Department of Molecular Pharmacology and Radiobiology, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0002-9441-3468.
Contact information: Elena N. Kareva, e-mail: kareva_e_n@staff.sechenov.ru.
Financial Disclosure: the author has no a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 20.01.2022.
Revised 14.02.2022.
Accepted 14.03.2022.
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