Solid organ transplantation and pregnancy
DOI: 10.32364/2618-8430-2021-4-4-333-338
M.A. Lysenko1, P.V. Kozlov2, V.M. Grabovskiy1, I.Yu. Kokaya1, I.P. Osokin1
1City Clinical Hospital No. 52, Moscow, Russian Federation
2Pirogov Russian National Research Medical University, Moscow, Russian Federation
This paper highlights the management of pregnancy, delivery, and the postpartum period after solid organ transplantation. First, statistical data on the prevalence and pattern of organ transplantation are addressed. The most relevant issues of pregnancy management in organ transplant recipients include identifying optimal criteria of transplant function monitoring, assessment of pregnancy and medication effects on the fetus, and pregnancy complication development. Next, the authors review major pharmacological classes of immunosuppressive therapy, pregnancy risks, complications, and outcomes associated with these medications, relevant pregnancy planning and management issues, and delivery in liver and kidney transplant recipients. Finally, the effect of breastfeeding (in the context of regular immunosuppressive therapy) on the postnatal period is discussed. Current data demonstrate that favorable pregnancy outcome after organ transplantation is most likely at least one year after transplantation in case of stable organ functioning, careful monitoring of recipient and transplant, adequate immunosuppressive therapy, diagnostic monitoring of fetus throughout pregnancy, and timely delivery.
Keywords: pregnancy, transplantation, liver, kidney, immunosuppressive therapy, complications, breastfeeding.
For citation: Lysenko M.A., Kozlov P.V., Grabovskiy V.M. et al. Solid organ transplantation and pregnancy. Russian Journal of Woman and Child Health. 2021;4(4):333–338 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-333-338.
About the authors:
Maryana A. Lysenko — Dr. Sc. (Med.), Head Doctor, City Clinical Hospital No. 52; 3, Pekhotnaya str., Moscow, 123182, Russian Federation; ORCID iD 0000-0002-2636-2558.
Pavel V. Kozlov — Dr. Sc. (Med.), professor of the Department of Obstetrics and Gynecology of the Medical Faculty, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0002-9916-6128.
Vasiliy M. Grabovskiy — Deputy Head Doctor for Obstetrical Gynecological Service, City Clinical Hospital No. 52; 3, Pekhotnaya str., Moscow, 123182, Russian Federation; ORCID iD 0000-0002-7048-4827.
Inga Yu. Kokaya — C. Sc. (Med.), Head of the Maternity Department, City Clinical Hospital No. 52; 3, Pekhotnaya str., Moscow, 123182, Russian Federation; ORCID iD 0000-0002-0637-1537.
Ivan P. Osokin — Head of the Department of Pregnancy Complications, City Clinical Hospital No. 52; 3, Pekhotnaya str., Moscow, 123182, Russian Federation; ORCID iD 0000-0003-2957-7236.
Contact information: Pavel V. Kozlov, e-mail: drkpv@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 23.09.2021.
Revised 18.10.2021.
Accepted 12.11.2021.
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