New methods for the treatment and prevention of anemia during pregnancy
DOI: 10.32364/2618-8430-2024-7-1-4
Yu.E. Dobrokhotova, V.V. Romanovskaya, M.R. Narimanova
Pirogov Russian National Research Medical University, Moscow, Russian Federation
Iron deficiency anemia is the most common extragenital pathology in pregnancy. Its relevance is determined by its impact on obstetric and perinatal outcomes, since iron deficiency negatively affects the course of pregnancy and fetal development. Timely detection, treatment, and prevention of iron deficiency conditions during pregnancy are necessary to reduce the risk of complications. The article discusses the main issues and criteria of rational diagnosis and modern approaches to the anemia treatment. It notes the importance of timely and full correction of iron deficiency to avoid the development of fetal neurocognitive disorders. Special attention is paid to the choice of iron products, the benefits and drawbacks of various forms of iron that limit their use in pregnant women. Separately, an innovative dosage form sucrosomal® iron is viewed, which can be considered as an effective means of treating this pathology. The article also presents the clinical studies and pharmacokinetic characteristics of oral sucrosomal iron, using which the necessary effect is achieved with lower doses in the absence of adverse events, which is of paramount importance during gestation.
Keywords: anemia of pregnancy, iron deficiency anemia, iron deficiency, iron preparations, sucrosomal iron, sucrosome.
For citation: Dobrokhotova Yu.E., Romanovskaya V.V., Narimanova M.R. New methods for the treatment and prevention of anemia during pregnancy. Russian Journal of Woman and Child Health. 2024;7(1):26–34 (in Russ.). DOI: 10.32364/2618-8430-2024-7-1-4.
About the authors:
Yulia E. Dobrokhotova — Dr. Sc. (Med.), Professor, Head of the Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117997, Russian Federation; ORCID iD 0000-0002-7830-2290.
Valentiva V. Romanovskaya — C. Sc. (Med.), assistant of the Department of Obstetrics and Gynecology, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0003-0413-5431.
Metanat R. Narimanova — C. Sc. (Med.), associate professor of the Department of Obstetrics & Gynecology, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0003-0677-2952.
Contact information: Valentiva V. Romanovskaya, e-mail: valentinaromano2005@yandex.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 30.11.2023.
Revised 20.12.2023.
Accepted 15.01.2024.
References
1. Anemia in Pregnancy: ACOG Practice Bulletin, Number 233. Obstet Gynecol. 2021;138(2):e55–e64. DOI: 10.1097/AOG.0000000000004477.
2. Breymann C. Iron Deficiency Anemia in Pregnancy. Semin Hematol. 2015;52(4):339–347. DOI: 10.1053/j.seminhematol.2015.07.003.
3. Bothwell T.H. Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr. 2000;72(1 Suppl):257S–264S. DOI: 10.1093/ajcn/72.1.257S.
4. Доброхотова Ю.Э., Бахарева И.В. Железодефицитная анемия беременных: профилактика и лечение. РМЖ. Мать и дитя. 2018;26(2(I)):59–64. [Dobrokhotova Yu.E., Bakhareva I.V. Iron deficiency anemia of pregnant women: prevention and treatment. RMJ. 2018;2(I):59–64 (in Russ.)].
5. Доброхотова Ю.Э., Маркова Э.А. Анемия беременных. Рациональная профилактика. Доказательная база. Актуальные вопросы женского здоровья. 2022;(1):50–56. DOI: 10.46393/2713122X_2022_1_50. [Dobrokhotova Yu.E., Markova E.A. Anemia of pregnant women. Rational prevention. The evidence base. Topical Issues of Women's Health. 2022;(1):50–56 (in Russ.)]. DOI: 10.46393/2713122X_2022_1_50.
6. Shi H., Chen L., Wang Y. et al. Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes. JAMA Netw Open. 2022;5(2):e2147046. DOI: 10.1001/jamanetworkopen.2021.47046.
7. Daru J., Zamora J., Fernández-Félix B.M. et al. Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis. Lancet Glob Health. 2018;6(5):e548–e554. DOI: 10.1016/S2214-109X(18)30078-0.
8. Wiegersma A.M., Dalman C., Lee B.K. et al. Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders. JAMA Psychiatry. 2019;76(12):1294–1304. DOI: 10.1001/jamapsychiatry.2019.2309.
9. Auerbach M., Abernathy J., Juul S. et al. Prevalence of iron deficiency in first trimester, nonanemic pregnant women. J Matern Fetal Neonatal Med. 2021;34(6):1002–1005. DOI: 10.1080/14767058.2019.1619690.
10. Teichman J., Nisenbaum R., Lausman A., Sholzberg M. Suboptimal iron deficiency screening in pregnancy and the impact of socioeconomic status in a high-resource setting. Blood Adv. 2021;5(22):4666–4673. DOI: 10.1182/bloodadvances.2021004352.
11. Cantor A.G., Bougatsos C., Dana T. et al. Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2015;162(8):566–576. DOI: 10.7326/M14-2932.
12. Achebe M.M., Gafter-Gvili A. How I treat anemia in pregnancy: iron, cobalamin, and folate. Blood. 2017;129(8):940–949. DOI: 10.1182/blood-2016-08-672246.
13. Peña-Rosas J.P., De-Regil L.M., Garcia-Casal M.N., Dowswell T. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015;2015(7):CD004736. DOI: 10.1002/14651858.CD004736.pub5.
14. MacQueen B.C., Christensen R.D., Ward D.M. et al. The iron status at birth of neonates with risk factors for developing iron deficiency: a pilot study. J Perinatol. 2017;37(4):436–440. DOI: 10.1038/jp.2016.234.
15. Tolkien Z., Stecher L., Mander A.P. et al. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One. 2015;10(2):e0117383. DOI: 10.1371/journal.pone.0117383.
16. Атаджанян А.С., Зайнулина М.С., Малаховская Е.А. Сравнительная эффективность внутривенных и таблетированных препаратов железа у беременных с анемией. Журнал акушерства и женских болезней. 2019;68(2):23–32. DOI: 10.17816/JOWD68223-32. [Atajanyan A.S., Zaynulina M.S., Malakhovskaya E.A. Comparative efficiency of intravenous and oral iron preparations in anemic pregnant women. Journal of Obstetrics and Women's Diseases. 2019;68(2):23–32 (in Russ.)]. DOI: 10.17816/JOWD68223-32.
17. Мартынов А.И., Малявин А.Г., Лукина Е.А. и др. Резолюция Совета экспертов «Железодефицитная анемия». Терапия. 2023;5:142–147. DOI: 10.18565/therapy.2023.5.142-147. [Martynov A.I., Malyavin A.G., Lukina E.A. et al. Resolution of the Expert council "Iron-deficiency anemia". Therapy. 2023;5:142–147 (in Russ.)]. DOI: 10.18565/therapy.2023.5.142-147.
18. Pavord S., Daru J., Prasannan N. et al.; BSH Committee. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020;188(6):819–830. DOI: 10.1111/bjh.16221.
19. Tariq N., Ayub R., Khan W.U. et al. Parenteral iron therapy in the treatment of iron deficiency anemia during pregnancy: a randomized controlled trial. J Coll Physicians Surg Pak. 2015;25(3):193–197.
20. Sultan P., Bampoe S., Shah R. et al. Oral vs intravenous iron therapy for postpartum anemia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2019;221(1):19–29.e3. DOI: 10.1016/j.ajog.2018.12.016.
21. Wesström J. Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy. Arch Gynecol Obstet. 2020;301(5):1127–1131. DOI: 10.1007/s00404-020-05509-2.
22. Гоззард Д. Когда требуется насыщение высокими дозами внутривенного железа? Оценка новых методов лечения. Акушерство и гинекология: новости, мнения, обучение. 2014;4:105–115. [Gozzard D. When is high-dose intravenous iron repletion needed? Assessing new treatment options. Obstetrics and gynecology. News, Opinions, Training. 2014;4:105–115 (in Russ.)].
23. Тютюнник В.Л. Современные принципы лекарственной терапии железодефицитной анемии у беременных. Мать и дитя. 2016;1(4). (Электронный ресурс.) URL: https://ru.aig-journal.ru/articles/Sovremennye-principy-lekarstvennoi-terapii-jelezodeficitnoi-anemii-u-beremennyh.html?ysclid=lsdkxfa7o0875543071. (дата обращения: 21.01.2024). [Tyutyunnik V.L. Modern principles of drug therapy for iron deficiency anemia in pregnant women. Mat' i ditya. 2016;1(4). (Electronic resource.) URL: https://ru.aig-journal.ru/articles/Sovremennye-principy-lekarstvennoi-terapii-jelezodeficitnoi-anemii-u-beremennyh.html?ysclid=lsdkxfa7o0875543071 (in Russ.) (access date: 21.01.2024)].
24. Моисеев С.В. Внутривенные препараты железа в лечении железодефицитной анемии. Фарматека. 2015;20:78–82. [Moiseev S.V. Intravenous iron supplements in the treatment of iron deficiency anemia. Pharmateca. 2015;20:78–82 (in Russ.)].
25. Liles A.M. Intravenous Versus Oral Iron for Treatment of Iron Deficiency in Non-hemodialysis-dependent Patients With Chronic Kidney Disease. Am J Health Syst Pharm. 2012;69(14):1206–1211.
26. Тютюнник В.Л., Кан Н.Е., Михайлова О.И., Дубровина Н.В. Оценка эффективности терапии железодефицитной анемии у беременных препаратом Мальтофер. Эффективная фармакотерапия. Акушерство и гинекология. 2017;26:4–10. [Tyutyunnik V.L., Kan N.E., Mikhailova O.I., Dubrovina N.V. Evaluation of Effectiveness of Iron-Deficiency Anemia Therapy during Pregnancy by Maltofer. Effektivnaya farmakoterapiya. Akusherstvo i ginekologiya. 2017;26:4–10 (in Russ.)].
27. Вялов С.С. Эффективность и безопасность липосомального железа в лечении анемии после резекции желудка или кишечника. Клиническая фармакология и терапия. 2016;25(4):42–46. [Vyalov S.S. Efficacy and safety of liposomal iron in the treatment for anemia after gastric or intestinum resection. Clin Farmacol Ther. 2016;25(4):42–46 (in Russ.)].
28. Malhotra J., Garg R., Malhotra N. Agrawal P. Oral Liposomal Iron: A Treatment Proposal for Anemia. World J Anemia. 2017;1(4):1–6.
29. Кононова И.Н., Карева Е.Н., Доброхотова Ю.Э. Активный метаболит 4-го поколения фолиевой кислоты Quatrefolic® и микронизированное микроинкапсулированное железо Lipofer®: инновационные подходы в восполнении дефицита фолиевой кислоты и железа у женщин. Обзор литературы. РМЖ. Мать и дитя. 2022;5(1):18–27. DOI: 10.32364/2618-8430-2022-5-1-18-27. [Kononova I.N., Kareva E.N., Dobrokhotova Yu.E. Fourth-generation folic acid active metabolite Quatrefolic® and micronized, microencapsulated iron Lipofer®: innovative approaches for iron and folic acid deficiencies in women (a review). Russian Journal of Woman and Child Health. 2022;5(1):18–27 (in Russ.)]. DOI: 10.32364/2618-8430-2022-5-1-18-27.
30. Tarantino G., Brilli E., Zambito Y. et al. Sucrosomial® iron: A new highly bioavailable oral iron supplement. Blood. 2015;126:4561–4562.
31. Brilli E., Romano A., Fabiano A. et al. Sucrosomial® technology is able to promote ferric iron absorption: Pre-clinical and clinical evidences. Blood. 2016;128:3618.
32. Gómez-Ramírez S., Brilli E., Tarantino G., Muñoz M. Sucrosomial® Iron: A New Generation Iron for Improving Oral Supplementation. Pharmaceuticals (Basel). 2018;11(4):97. DOI: 10.3390/ph11040097.
33. Visciano B., Nazzaro P., Tarantino G. et al. Liposomial iron: a new proposal for the treatment of anaemia in chronic kidney disease. G Ital Nefrol. 2013;30(5):gin/30.5.7 (in Italian). PMID: 24402627.
34. Орешко Л.С., Соловьева Е.А. Анемические проявления при синдроме мальабсорбции и их коррекция. Гастроэнтерология Санкт-Петербурга. 2016;1–2:2–5. [Oreshko L.S., Solovyova E.A. Anemic manifestations of malabsorption syndrome and their correction. Gastroenterologiya Sankt-Peterburga. 2016;1–2:2–5 (in Russ.)].
35. Стуклов Н.И., Князев О.В., Парфенов А.И. и др. Сравнительная эффективность применения новой сукросомальной формы железа для перорального приема и внутривенной ферротерапии в лечении анемий у больных воспалительными заболеваниями кишечника. Клиническая медицина. 2017;95(12):1112–1117. DOI: 10.18821/0023-2149-2017-95-12-1112-1117. [Stuklov N.I., Knyazev O.V., Parfenov A.I. et al. Comparison of efficiency of a new sucrosomal peroral form of iron with intravenous ferrotherapy in the treatment of anemia in inflammatory bowel diseases. Klin med. 2017;95(12):1112–1117 (in Russ.)]. DOI: 10.18821/0023-2149-2017-95-12-1112-1117.
36. Antunes C.V., Chebli L., Ribeiro T. et al. Treatment of Iron Deficiency Anemia With Oral Liposomal Iron in IBD: A Pilot Study Evaluating the Efficacy and Safety. AJG. 2019;114:S5–S6. DOI: 10.14309/01.ajg.0000613044.04856.81.
37. Минушкин О.Н., Иванова О.И., Евсиков А.Е. Новые технологии лечения железодефицитных анемий. Эффективная фармакотерапия. 2022;18(42):64–68. DOI: 10.33978/2307-3586-2022-18-42-64-68. [Minushkin O.N., Ivanova O.I., Evsikov A.E. New Technologies for the Treatment of Iron Deficiency Anemia. Effective pharmacotherapy. 2022;18(42):64–68 (in Russ.)]. DOI: 10.33978/2307-3586-2022-18-42-64-68.
38. Кононова И.Н., Доброхотова Ю.Э., Карева Е.Н. и др. Оценка эффективности сукросомальной формы железа при лечении пациенток с железодефицитной анемией 1–2-й степени тяжести на фоне обильных менструальных кровотечений. РМЖ. Мать и дитя. 2023;6(4):332–339. DOI: 10.32364/2618-8430-2023-6-4-2. [Kononova I.N., Dobrokhotova Yu.E., Kareva E.N. et al. Evaluation of the sucrosomial iron efficacy in the patient treatment with stage 1–2 iron deficiency anemia during heavy menstrual bleeding. Russian Journal of Woman and Child Health. 2023;6(4):332–339 (in Russ.)]. DOI: 10.32364/2618-8430-2023-6-4-2.
39. Радзинский В.Е., Ордиянц И.М., Побединская О.С. Железодефицитная анемия как фактор риска плацентарной недостаточности и перинатальных осложнений. Акушерство и гинекология. 2016;12:125–130. DOI: 10.18565/aig.2016.12.125-30. [Radzinsky V.E., Ordiyants I.M., Pobedinskaya O.S. Iron deficiency anemia is a risk factor for placental insufficiency and perinatal complications. Obstetrics and Gynegology. 2016;12:125–130 (in Russ.)]. DOI: 10.18565/aig.2016.12.125-30.
40. Antoine E., Mehedintu C., Mitran M., Diculescu D. Sucrosomial® iron effectiveness in recovering from mild and moderate iron-deficiency anemia in the postpartum period. BMC Pregnancy Childbirth. 2023;23(1):360. DOI: 10.1186/s12884-023-05658-7.
2. Breymann C. Iron Deficiency Anemia in Pregnancy. Semin Hematol. 2015;52(4):339–347. DOI: 10.1053/j.seminhematol.2015.07.003.
3. Bothwell T.H. Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr. 2000;72(1 Suppl):257S–264S. DOI: 10.1093/ajcn/72.1.257S.
4. Доброхотова Ю.Э., Бахарева И.В. Железодефицитная анемия беременных: профилактика и лечение. РМЖ. Мать и дитя. 2018;26(2(I)):59–64. [Dobrokhotova Yu.E., Bakhareva I.V. Iron deficiency anemia of pregnant women: prevention and treatment. RMJ. 2018;2(I):59–64 (in Russ.)].
5. Доброхотова Ю.Э., Маркова Э.А. Анемия беременных. Рациональная профилактика. Доказательная база. Актуальные вопросы женского здоровья. 2022;(1):50–56. DOI: 10.46393/2713122X_2022_1_50. [Dobrokhotova Yu.E., Markova E.A. Anemia of pregnant women. Rational prevention. The evidence base. Topical Issues of Women's Health. 2022;(1):50–56 (in Russ.)]. DOI: 10.46393/2713122X_2022_1_50.
6. Shi H., Chen L., Wang Y. et al. Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes. JAMA Netw Open. 2022;5(2):e2147046. DOI: 10.1001/jamanetworkopen.2021.47046.
7. Daru J., Zamora J., Fernández-Félix B.M. et al. Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis. Lancet Glob Health. 2018;6(5):e548–e554. DOI: 10.1016/S2214-109X(18)30078-0.
8. Wiegersma A.M., Dalman C., Lee B.K. et al. Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders. JAMA Psychiatry. 2019;76(12):1294–1304. DOI: 10.1001/jamapsychiatry.2019.2309.
9. Auerbach M., Abernathy J., Juul S. et al. Prevalence of iron deficiency in first trimester, nonanemic pregnant women. J Matern Fetal Neonatal Med. 2021;34(6):1002–1005. DOI: 10.1080/14767058.2019.1619690.
10. Teichman J., Nisenbaum R., Lausman A., Sholzberg M. Suboptimal iron deficiency screening in pregnancy and the impact of socioeconomic status in a high-resource setting. Blood Adv. 2021;5(22):4666–4673. DOI: 10.1182/bloodadvances.2021004352.
11. Cantor A.G., Bougatsos C., Dana T. et al. Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2015;162(8):566–576. DOI: 10.7326/M14-2932.
12. Achebe M.M., Gafter-Gvili A. How I treat anemia in pregnancy: iron, cobalamin, and folate. Blood. 2017;129(8):940–949. DOI: 10.1182/blood-2016-08-672246.
13. Peña-Rosas J.P., De-Regil L.M., Garcia-Casal M.N., Dowswell T. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2015;2015(7):CD004736. DOI: 10.1002/14651858.CD004736.pub5.
14. MacQueen B.C., Christensen R.D., Ward D.M. et al. The iron status at birth of neonates with risk factors for developing iron deficiency: a pilot study. J Perinatol. 2017;37(4):436–440. DOI: 10.1038/jp.2016.234.
15. Tolkien Z., Stecher L., Mander A.P. et al. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One. 2015;10(2):e0117383. DOI: 10.1371/journal.pone.0117383.
16. Атаджанян А.С., Зайнулина М.С., Малаховская Е.А. Сравнительная эффективность внутривенных и таблетированных препаратов железа у беременных с анемией. Журнал акушерства и женских болезней. 2019;68(2):23–32. DOI: 10.17816/JOWD68223-32. [Atajanyan A.S., Zaynulina M.S., Malakhovskaya E.A. Comparative efficiency of intravenous and oral iron preparations in anemic pregnant women. Journal of Obstetrics and Women's Diseases. 2019;68(2):23–32 (in Russ.)]. DOI: 10.17816/JOWD68223-32.
17. Мартынов А.И., Малявин А.Г., Лукина Е.А. и др. Резолюция Совета экспертов «Железодефицитная анемия». Терапия. 2023;5:142–147. DOI: 10.18565/therapy.2023.5.142-147. [Martynov A.I., Malyavin A.G., Lukina E.A. et al. Resolution of the Expert council "Iron-deficiency anemia". Therapy. 2023;5:142–147 (in Russ.)]. DOI: 10.18565/therapy.2023.5.142-147.
18. Pavord S., Daru J., Prasannan N. et al.; BSH Committee. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020;188(6):819–830. DOI: 10.1111/bjh.16221.
19. Tariq N., Ayub R., Khan W.U. et al. Parenteral iron therapy in the treatment of iron deficiency anemia during pregnancy: a randomized controlled trial. J Coll Physicians Surg Pak. 2015;25(3):193–197.
20. Sultan P., Bampoe S., Shah R. et al. Oral vs intravenous iron therapy for postpartum anemia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2019;221(1):19–29.e3. DOI: 10.1016/j.ajog.2018.12.016.
21. Wesström J. Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy. Arch Gynecol Obstet. 2020;301(5):1127–1131. DOI: 10.1007/s00404-020-05509-2.
22. Гоззард Д. Когда требуется насыщение высокими дозами внутривенного железа? Оценка новых методов лечения. Акушерство и гинекология: новости, мнения, обучение. 2014;4:105–115. [Gozzard D. When is high-dose intravenous iron repletion needed? Assessing new treatment options. Obstetrics and gynecology. News, Opinions, Training. 2014;4:105–115 (in Russ.)].
23. Тютюнник В.Л. Современные принципы лекарственной терапии железодефицитной анемии у беременных. Мать и дитя. 2016;1(4). (Электронный ресурс.) URL: https://ru.aig-journal.ru/articles/Sovremennye-principy-lekarstvennoi-terapii-jelezodeficitnoi-anemii-u-beremennyh.html?ysclid=lsdkxfa7o0875543071. (дата обращения: 21.01.2024). [Tyutyunnik V.L. Modern principles of drug therapy for iron deficiency anemia in pregnant women. Mat' i ditya. 2016;1(4). (Electronic resource.) URL: https://ru.aig-journal.ru/articles/Sovremennye-principy-lekarstvennoi-terapii-jelezodeficitnoi-anemii-u-beremennyh.html?ysclid=lsdkxfa7o0875543071 (in Russ.) (access date: 21.01.2024)].
24. Моисеев С.В. Внутривенные препараты железа в лечении железодефицитной анемии. Фарматека. 2015;20:78–82. [Moiseev S.V. Intravenous iron supplements in the treatment of iron deficiency anemia. Pharmateca. 2015;20:78–82 (in Russ.)].
25. Liles A.M. Intravenous Versus Oral Iron for Treatment of Iron Deficiency in Non-hemodialysis-dependent Patients With Chronic Kidney Disease. Am J Health Syst Pharm. 2012;69(14):1206–1211.
26. Тютюнник В.Л., Кан Н.Е., Михайлова О.И., Дубровина Н.В. Оценка эффективности терапии железодефицитной анемии у беременных препаратом Мальтофер. Эффективная фармакотерапия. Акушерство и гинекология. 2017;26:4–10. [Tyutyunnik V.L., Kan N.E., Mikhailova O.I., Dubrovina N.V. Evaluation of Effectiveness of Iron-Deficiency Anemia Therapy during Pregnancy by Maltofer. Effektivnaya farmakoterapiya. Akusherstvo i ginekologiya. 2017;26:4–10 (in Russ.)].
27. Вялов С.С. Эффективность и безопасность липосомального железа в лечении анемии после резекции желудка или кишечника. Клиническая фармакология и терапия. 2016;25(4):42–46. [Vyalov S.S. Efficacy and safety of liposomal iron in the treatment for anemia after gastric or intestinum resection. Clin Farmacol Ther. 2016;25(4):42–46 (in Russ.)].
28. Malhotra J., Garg R., Malhotra N. Agrawal P. Oral Liposomal Iron: A Treatment Proposal for Anemia. World J Anemia. 2017;1(4):1–6.
29. Кононова И.Н., Карева Е.Н., Доброхотова Ю.Э. Активный метаболит 4-го поколения фолиевой кислоты Quatrefolic® и микронизированное микроинкапсулированное железо Lipofer®: инновационные подходы в восполнении дефицита фолиевой кислоты и железа у женщин. Обзор литературы. РМЖ. Мать и дитя. 2022;5(1):18–27. DOI: 10.32364/2618-8430-2022-5-1-18-27. [Kononova I.N., Kareva E.N., Dobrokhotova Yu.E. Fourth-generation folic acid active metabolite Quatrefolic® and micronized, microencapsulated iron Lipofer®: innovative approaches for iron and folic acid deficiencies in women (a review). Russian Journal of Woman and Child Health. 2022;5(1):18–27 (in Russ.)]. DOI: 10.32364/2618-8430-2022-5-1-18-27.
30. Tarantino G., Brilli E., Zambito Y. et al. Sucrosomial® iron: A new highly bioavailable oral iron supplement. Blood. 2015;126:4561–4562.
31. Brilli E., Romano A., Fabiano A. et al. Sucrosomial® technology is able to promote ferric iron absorption: Pre-clinical and clinical evidences. Blood. 2016;128:3618.
32. Gómez-Ramírez S., Brilli E., Tarantino G., Muñoz M. Sucrosomial® Iron: A New Generation Iron for Improving Oral Supplementation. Pharmaceuticals (Basel). 2018;11(4):97. DOI: 10.3390/ph11040097.
33. Visciano B., Nazzaro P., Tarantino G. et al. Liposomial iron: a new proposal for the treatment of anaemia in chronic kidney disease. G Ital Nefrol. 2013;30(5):gin/30.5.7 (in Italian). PMID: 24402627.
34. Орешко Л.С., Соловьева Е.А. Анемические проявления при синдроме мальабсорбции и их коррекция. Гастроэнтерология Санкт-Петербурга. 2016;1–2:2–5. [Oreshko L.S., Solovyova E.A. Anemic manifestations of malabsorption syndrome and their correction. Gastroenterologiya Sankt-Peterburga. 2016;1–2:2–5 (in Russ.)].
35. Стуклов Н.И., Князев О.В., Парфенов А.И. и др. Сравнительная эффективность применения новой сукросомальной формы железа для перорального приема и внутривенной ферротерапии в лечении анемий у больных воспалительными заболеваниями кишечника. Клиническая медицина. 2017;95(12):1112–1117. DOI: 10.18821/0023-2149-2017-95-12-1112-1117. [Stuklov N.I., Knyazev O.V., Parfenov A.I. et al. Comparison of efficiency of a new sucrosomal peroral form of iron with intravenous ferrotherapy in the treatment of anemia in inflammatory bowel diseases. Klin med. 2017;95(12):1112–1117 (in Russ.)]. DOI: 10.18821/0023-2149-2017-95-12-1112-1117.
36. Antunes C.V., Chebli L., Ribeiro T. et al. Treatment of Iron Deficiency Anemia With Oral Liposomal Iron in IBD: A Pilot Study Evaluating the Efficacy and Safety. AJG. 2019;114:S5–S6. DOI: 10.14309/01.ajg.0000613044.04856.81.
37. Минушкин О.Н., Иванова О.И., Евсиков А.Е. Новые технологии лечения железодефицитных анемий. Эффективная фармакотерапия. 2022;18(42):64–68. DOI: 10.33978/2307-3586-2022-18-42-64-68. [Minushkin O.N., Ivanova O.I., Evsikov A.E. New Technologies for the Treatment of Iron Deficiency Anemia. Effective pharmacotherapy. 2022;18(42):64–68 (in Russ.)]. DOI: 10.33978/2307-3586-2022-18-42-64-68.
38. Кононова И.Н., Доброхотова Ю.Э., Карева Е.Н. и др. Оценка эффективности сукросомальной формы железа при лечении пациенток с железодефицитной анемией 1–2-й степени тяжести на фоне обильных менструальных кровотечений. РМЖ. Мать и дитя. 2023;6(4):332–339. DOI: 10.32364/2618-8430-2023-6-4-2. [Kononova I.N., Dobrokhotova Yu.E., Kareva E.N. et al. Evaluation of the sucrosomial iron efficacy in the patient treatment with stage 1–2 iron deficiency anemia during heavy menstrual bleeding. Russian Journal of Woman and Child Health. 2023;6(4):332–339 (in Russ.)]. DOI: 10.32364/2618-8430-2023-6-4-2.
39. Радзинский В.Е., Ордиянц И.М., Побединская О.С. Железодефицитная анемия как фактор риска плацентарной недостаточности и перинатальных осложнений. Акушерство и гинекология. 2016;12:125–130. DOI: 10.18565/aig.2016.12.125-30. [Radzinsky V.E., Ordiyants I.M., Pobedinskaya O.S. Iron deficiency anemia is a risk factor for placental insufficiency and perinatal complications. Obstetrics and Gynegology. 2016;12:125–130 (in Russ.)]. DOI: 10.18565/aig.2016.12.125-30.
40. Antoine E., Mehedintu C., Mitran M., Diculescu D. Sucrosomial® iron effectiveness in recovering from mild and moderate iron-deficiency anemia in the postpartum period. BMC Pregnancy Childbirth. 2023;23(1):360. DOI: 10.1186/s12884-023-05658-7.
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